Rv1323

Tuberculist information
Gene namefadA4
Protein functionProbable acetyl-CoA acetyltransferase FadA4 (acetoacetyl-CoA thiolase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1485.86
Molecular mass(da)40048.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 389
	  		  	1    VIVAGARTPIGKLMGSLKDFSASELGAIAIKGALEKANVPASLVEYVIMGQVLTAGAGQM   60
			  	61   PARQAAVAAGIGWDVPALTINKMCLSGIDAIALADQLIRAREFDVVVAGGQESMTKAPHL  120
			  	121  LMNSRSGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQRNDVDMFTRSEQDEYAAASHQ  180
			  	181  KAAAAWKDGVFADEVIPVNIPQRTGDPLQFTEDEGIRANTTAAALAGLKPAFRGDGTITA  240
			  	241  GSASQISDGAAAVVVMNQEKAQELGLTWLAEIGAHGVVAGPDSTLQSQPANAINKALDRE  300
			  	301  GISVDQLDVVEINEAFAAVALASIRELGLNPQIVNVNGGAIAVGHPLGMSGTRITLHAAL  360
			  	361  QLARRGSGVGVAALCGAGGQGDALILRAG

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 1 to 259  |  Coverage: 66% Thiolase_N Range: 266 to 388  |  Coverage: 31% Thiolase_C Range: 1 to 387  |  Coverage: 99% 1 Range: 1 to 259  |  Coverage: 66% 1
Number of amino acids : 389
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_NPF001081-259
Thiolase_CPF02803266-388
Mtb Structural Proteome models
Model Number1
Model nameRv1323
Template1M3K    APDBCREDO
Template coverage6_390
Template Identity(%)44.2
Model coverage(%)99.2
Normalized DOPE score-0.39

Structure Models from Chopin
Model Number1
Profilec.95.1.1
Click for model details
zscore49.15
Residue begin1
Residue end259
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1323Gene nameConfidence Score
Rv2504cscoA0.991
Rv2503cscoB0.985
Rv0468fadB20.984
Rv0468fadB20.984
Rv0860fadB0.976
Rv0860fadB0.976
Rv0860fadB0.976
Rv1144Rv11440.972
Rv1715fadB30.962
Rv1715fadB30.962
Rv3667acs0.959
Rv3667acs0.959
Rv0896gltA20.953
Rv0408pta0.949
Rv0408pta0.949
Rv0408pta0.949
Rv1135ARv1135A0.941
Rv0975cfadE130.937
Rv0975cfadE130.937
Rv0975cfadE130.937
Rv2790cltp10.933
Rv2790cltp10.933
Rv3535chsaG0.927
Rv3535chsaG0.927
Rv0904caccD30.924
Rv1131prpC0.923
Rv2495cbkdC0.922
Rv2495cbkdC0.922
Rv2495cbkdC0.922
Rv0154cfadE20.921
Rv0154cfadE20.921
Rv0154cfadE20.921
Rv3140fadE230.914
Rv3140fadE230.914
Rv0889ccitA0.907
Rv0131cfadE10.905
Rv0131cfadE10.905
Rv0131cfadE10.905
Rv3710leuA0.902
Rv3710leuA0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.974851.607
acetyl-CoAPubChem0.956809.571
coenzyme APubChem0.939767.534
3-hydroxybutyryl-CoAPubChem0.928853.623
butyryl-CoAPubChem0.923837.624
Co-APubChem0.92767.534
3-ketohexanoyl-CoAPubChem0.901879.661
NAD+PubChem0.901663.425
pyruvic acidPubChem0.988.0621
acetyl coenzyme-APubChem0.9809.571
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
acetoacetyl-S-CoAPubChem0.9851.607
carbon dioxidePubChem0.944.0095
H(+)PubChem0.92.01588