Rv1135A

Tuberculist information
Gene nameRv1135A
Protein functionPossible acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1264.31
Molecular mass(da)8801.14
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 80
	  		  	1    MQLGNQNTMRFAGRPQRFRQSAYPLFNPNSAIALGHPFGGSGARLMTTVLHHMPDKGIRY   60
			  	61   GLQTMCEGRGQANATIVELL

Known structures in the PDB
No Known structures
1 9 17 25 33 41 49 57 65 73 81 Range: 16 to 79  |  Coverage: 78% Thiolase_C Range: 5 to 78  |  Coverage: 91% 1
Number of amino acids : 80
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_CPF0280316-79
Mtb Structural Proteome models
Model Number1
Model nameRv1135A
Template1ULQ    APDBCREDO
Template coverage322_398
Template Identity(%)41.9
Model coverage(%)90.1
Normalized DOPE score-0.187

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
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Protein interacting with Rv1135AGene nameConfidence Score
Rv1323fadA40.941
Rv1323fadA40.941
Rv0231fadE40.934
Rv0131cfadE10.934
Rv0231fadE40.934
Rv0131cfadE10.934
Rv0131cfadE10.934
Rv0154cfadE20.93
Rv0154cfadE20.93
Rv0154cfadE20.93
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetyl-CoAPubChem0.9809.571
3-ketohexanoyl-CoAPubChem0.9879.661
acetoacetyl-CoAPubChem0.9851.607
butyryl-CoAPubChem0.9837.624