Rv0131c

Tuberculist information
Gene namefadE1
Protein functionProbable acyl-CoA dehydrogenase FadE1
Functional category(tuberculist)lipid metabolism
Gene location(kb)158.315
Molecular mass(da)50223.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 447
	  		  	1    MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVALDPYDKKNADTMAIL   60
			  	61   RPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIIGRSRWAPSAFGCQAPDSGNAEI  120
			  	121  LALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLFVTAATRDAAGNGDWIINGEK  180
			  	181  WFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGY  240
			  	241  IRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSRQTR  300
			  	301  HGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRDIAAVKVAMPQVLH  360
			  	361  DVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATELHKMTVARRTLREYQPVTTLF  420
			  	421  PSQHIPTRRAHAEAWLAQRLEHAIAEF

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 21 to 141  |  Coverage: 26% Acyl-CoA_dh_N Range: 145 to 199  |  Coverage: 12% Acyl-CoA_dh_M Range: 258 to 410  |  Coverage: 34% Acyl-CoA_dh_1 Range: 18 to 414  |  Coverage: 88% 1 Range: 6 to 418  |  Coverage: 92% 1 Range: 256 to 422  |  Coverage: 37% 2 Range: 7 to 261  |  Coverage: 56% 3 Range: 142 to 270  |  Coverage: 28% 4 Range: 21 to 141  |  Coverage: 26% 5
Number of amino acids : 447
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF0277121-141
Acyl-CoA_dh_MPF02770145-199
Acyl-CoA_dh_1PF00441258-410
Mtb Structural Proteome models
Model Number1
Model nameRv0131c
Template1JQI    APDBCREDO
Template coverage9_387
Template Identity(%)27.7
Model coverage(%)88.6
Normalized DOPE score-0.574

Structure Models from Chopin
Model Number1
Profilea.29.3.1, e.6.1.1 - 1.10.540.10, 1.20.140.10, 2.40.110.10
Click for model details
zscore55.73
Residue begin6
Residue end418
Model Number2
Profilea.29.3.1
Click for model details
zscore33.13
Residue begin256
Residue end422
Model Number3
Profilee.6.1.1
Click for model details
zscore19.33
Residue begin7
Residue end261
Model Number4
Profile2.40.110.10
Click for model details
zscore19.29
Residue begin142
Residue end270
Model Number5
Profile1.10.540.10
Click for model details
zscore16.27
Residue begin21
Residue end141
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0131cGene nameConfidence Score
Rv3774echA210.943
Rv0675echA50.942
Rv1141cechA110.937
Rv2679echA150.937
Rv0456cechA20.937
Rv1135ARv1135A0.934
Rv1935cechA130.931
Rv0673echA40.931
Rv3550echA200.93
Rv1071cechA90.93
Rv1071cechA90.93
Rv2831echA160.93
Rv1142cechA100.928
Rv0971cechA70.92
Rv0222echA10.92
Rv0753cmmsA0.92
Rv0632cechA30.92
Rv1074cfadA30.919
Rv1074cfadA30.919
Rv3761cfadE360.919
Rv3556cfadA60.918
Rv3556cfadA60.918
Rv0859fadA0.916
Rv0859fadA0.916
Rv3516echA190.915
Rv0914cRv0914c0.914
Rv0914cRv0914c0.914
Rv0243fadA20.913
Rv0243fadA20.913
Rv3546fadA50.912
Rv3546fadA50.912
Rv1867Rv18670.912
Rv2790cltp10.906
Rv2790cltp10.906
Rv1323fadA40.905
Rv1323fadA40.905
Rv1058fadD140.901
Rv2502caccD10.901
Rv1058fadD140.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.915785.55
butyryl-CoAPubChem0.901837.624
myristoyl-CoAPubChem0.9977.89
3-methylcrotonyl-CoAPubChem0.9849.635
C05273PubChem0.9975.874
1,5-dihydro-FADPubChem0.9787.566
AR-1A9122PubChem0.9787.566
hexanoyl-CoAPubChem0.9865.677
adenosine triphosphatePubChem0.9507.181
C03221PubChem0.9947.821
2MCPubChem0.9835.608
Co-APubChem0.9767.534
lauroyl-CoAPubChem0.9949.837
formatePubChem0.945.0174
palmitoyl-CoAPubChem0.91005.94
FADH2PubChem0.9787.566
C05275PubChem0.9919.768
octanoyl-CoAPubChem0.9893.73
propionyl-CoAPubChem0.9823.597
protiumPubChem0.92.01576
trans-2-hexadecenoyl-CoAPubChem0.91003.93
NSC112207PubChem0.9785.55
methylcrotonyl CoAPubChem0.9849.635
adenosine monophosphatePubChem0.9347.221
C05276PubChem0.9891.714
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
decanoyl-CoAPubChem0.9921.783
hydroxyl radicalsPubChem0.917.0073
acryloyl-CoAPubChem0.9821.581
trans-2-enoyl-CoAsPubChem0.9821.581
coenzyme APubChem0.9767.534
pyrophosphatePubChem0.9177.975
methacrylyl-CoAPubChem0.9835.608
C05271PubChem0.9863.661
crotonyl-CoAPubChem0.9835.608