Rv0673

Tuberculist information
Gene nameechA4
Protein functionPossible enoyl-CoA hydratase EchA4 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)773.123
Molecular mass(da)33541.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 312
	  		  	1    MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTPLELSALVERADLDPGVH   60
			  	61   VILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAYQGTVLDGKTQAVNHLPNQPWDPMIDYQ  120
			  	121  MMSRFVRGFASLMHADKPTVVKIHGYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVP  180
			  	181  AAGLWAHRLGDQRAKRLLFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIAALPV  240
			  	241  NQLIMVKLALNSALLQQGVATSRMVSTVFDGAARHTPEGHAFVADAVEHGFRDAVRRRDE  300
			  	301  PFGDYGRQASRV

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 17 to 102  |  Coverage: 27% ECH Range: 115 to 280  |  Coverage: 52% ECH Range: 3 to 307  |  Coverage: 97% 1
Number of amino acids : 312
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF0037817-102
ECHPF00378115-280
Mtb Structural Proteome models
Model Number1
Model nameRv0673
Template1Q52    APDBCREDO
Template coverage23_312
Template Identity(%)24.0
Model coverage(%)97.4
Normalized DOPE score0.42

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0673Gene nameConfidence Score
Rv1550fadD110.95
Rv1715fadB30.944
Rv1715fadB30.944
Rv3562fadE310.934
Rv1679fadE160.934
Rv1934cfadE170.934
Rv1679fadE160.934
Rv1934cfadE170.934
Rv1679fadE160.934
Rv1934cfadE170.934
Rv3562fadE310.934
Rv3562fadE310.934
Rv1933cfadE180.933
Rv1933cfadE180.933
Rv0231fadE40.931
Rv0131cfadE10.931
Rv0231fadE40.931
Rv0131cfadE10.931
Rv3564fadE330.931
Rv0131cfadE10.931
Rv3564fadE330.931
Rv0154cfadE20.93
Rv3505fadE270.93
Rv1467cfadE150.93
Rv3505fadE270.93
Rv1467cfadE150.93
Rv0271cfadE60.93
Rv1467cfadE150.93
Rv0271cfadE60.93
Rv1467cfadE150.93
Rv0154cfadE20.93
Rv0271cfadE60.93
Rv1467cfadE150.93
Rv0154cfadE20.93
Rv0860fadB0.929
Rv0860fadB0.929
Rv0860fadB0.929
Rv3563fadE320.928
Rv3560cfadE300.928
Rv3563fadE320.928
Rv3560cfadE300.928
Rv3543cfadE290.928
Rv3560cfadE300.928
Rv3543cfadE290.928
Rv3543cfadE290.928
Rv3504fadE260.92
Rv3544cfadE280.92
Rv3504fadE260.92
Rv3504fadE260.92
Rv3544cfadE280.92
Rv0468fadB20.917
Rv0468fadB20.917
Rv1346mbtN0.915
Rv1346mbtN0.915
Rv1346mbtN0.915
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C05268PubChem0.9881.677
3-hydroxybutyryl-CoAPubChem0.9853.623
C04405PubChem0.9867.65
C0885PubChem0.9917.752
methylcrotonyl CoAPubChem0.9849.635
C16468PubChem0.9875.672
AR-1A9122PubChem0.9787.566
c0887PubChem0.9935.767
flavin adenine dinucleotidePubChem0.9785.55
3-hydroxypropionyl-CoAPubChem0.9839.597
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05271PubChem0.9863.661
deuteriumPubChem0.92.01588
C11945PubChem0.9917.752
C05262PubChem0.9965.836
2-methylbutyryl-CoAPubChem0.9851.651
C01144PubChem0.9853.623
C05273PubChem0.9975.874
NAD+PubChem0.9663.425
protiumPubChem0.92.01576
2-methylacetoacetyl-coenzyme APubChem0.9865.634
C05266PubChem0.9909.73
3-methylcrotonyl-CoAPubChem0.9849.635
methacrylyl-CoAPubChem0.9835.608
C03221PubChem0.9947.821
hydroxyl radicalsPubChem0.917.0073
CHEBI:15477PubChem0.9851.651
NSC112207PubChem0.9785.55
3-hydroxypropionyl-coenzyme APubChem0.9839.597
crotonyl-CoAPubChem0.9835.608
C05258PubChem0.91021.94
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C16469PubChem0.9893.687
H(+)PubChem0.92.01588
C05275PubChem0.9919.768
1,5-dihydro-FADPubChem0.9787.566
C11947PubChem0.9935.767
C05260PubChem0.9993.889
2-methylacetoacetyl-CoAPubChem0.9865.634
acryloyl-CoAPubChem0.9821.581
trans-2-hexadecenoyl-CoAPubChem0.91003.93
2MCPubChem0.9835.608
C14145PubChem0.9911.659
3-hydroxydecanoyl-CoAPubChem0.9937.783
3-hydroxyadipyl-CoAPubChem0.9911.659
FADH2PubChem0.9787.566
C05276PubChem0.9891.714
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C11946PubChem0.9917.752
alpha-methylbutyryl-CoAPubChem0.9851.651