Rv3563

Tuberculist information
Gene namefadE32
Protein functionProbable acyl-CoA dehydrogenase FadE32
Functional category(tuberculist)lipid metabolism
Gene location(kb)4004.29
Molecular mass(da)33455.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 319
	  		  	1    VTMEFALNEQQRDFAASIDAALGAADLPGVVRAWAAGDVAPGRKVWQQLANLGVTALGVA   60
			  	61   EKFDGLGASPVDLVVALERLGRWCVPGPVTESIAVAPILLAHDDQAERSHGLASGELIAT  120
			  	121  VAMPPRVPRAVDADTAGLVLLAGDGSVTEGTPGDCHRSVDPSRRLYEVAASGQAWRAPKD  180
			  	181  VVARAYEFGALATAAQLVGAGQALLEAAVNYAKQRTQFGRAIGSYQAIKHKLADVHIAIE  240
			  	241  LACPLVYGAAVSLEPRDVSAAKAAASEAALLAARWALQTHGAIGFTCEHDLSLWLLRVQA  300
			  	301  LHSAWGTPQEHRRRVLEAL

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 8 to 116  |  Coverage: 33% Acyl-CoA_dh_N Range: 180 to 319  |  Coverage: 43% Acyl-CoA_dh_1 Range: 3 to 316  |  Coverage: 98% 1 Range: 180 to 318  |  Coverage: 43% 1 Range: 1 to 319  |  Coverage: 99% 2 Range: 8 to 116  |  Coverage: 33% 3
Number of amino acids : 319
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027718-116
Acyl-CoA_dh_1PF00441180-319
Mtb Structural Proteome models
Model Number1
Model nameRv3563
Template1UKW    APDBCREDO
Template coverage32_403
Template Identity(%)31.8
Model coverage(%)97.8
Normalized DOPE score0.495

Structure Models from Chopin
Model Number1
Profilea.29.3.1
Click for model details
zscore33.83
Residue begin180
Residue end318
Model Number2
Profilea.29.3.1, e.6.1.1 - 1.10.540.10, 1.20.140.10, 2.40.110.10
Click for model details
zscore32.76
Residue begin1
Residue end319
Model Number3
Profile1.10.540.10
Click for model details
zscore9.42
Residue begin8
Residue end116
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3563Gene nameConfidence Score
Rv3561fadD30.987
Rv3561fadD30.987
Rv3552Rv35520.975
Rv3562fadE310.972
Rv3562fadE310.972
Rv3562fadE310.972
Rv3551Rv35510.968
Rv3550echA200.965
Rv1071cechA90.958
Rv1071cechA90.958
Rv1935cechA130.955
Rv3560cfadE300.943
Rv3560cfadE300.943
Rv3560cfadE300.943
Rv2679echA150.931
Rv0456cechA20.931
Rv0675echA50.93
Rv0222echA10.929
Rv2831echA160.928
Rv0673echA40.928
Rv1141cechA110.928
Rv3516echA190.922
Rv1142cechA100.92
Rv0632cechA30.919
Rv0971cechA70.919
Rv3774echA210.907
Rv1058fadD140.901
Rv1058fadD140.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
flavin adenine dinucleotidePubChem0.9785.55
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
adenosine monophosphatePubChem0.9347.221