Rv3560c

Tuberculist information
Gene namefadE30
Protein functionProbable acyl-CoA dehydrogenase FadE30
Functional category(tuberculist)lipid metabolism
Gene location(kb)4000.43
Molecular mass(da)42732.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 385
	  		  	1    MQDVEEFRAQVRGWLADNLAGEFAALKGLGGPGREHEAFEERRAWNQRLAAAGLTCLGWP   60
			  	61   EEHGGRGLSTAHRVAFYEEYARADAPDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDV  120
			  	121  TELWCQGYSEPGAGSDLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTEKGSQ  180
			  	181  RHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDDARTDADLVVGAPGDGWRVAMAT  240
			  	241  LTFERGVSTLGQQIVYARELSNLVELARRTAAADDPLIRERLTRAWTGLRAMRSYALATM  300
			  	301  EGPAVEQPGQDNVSKLLWANWHRNLGELAMDVIGKPGMTMPDGEFDEWQRLYLFTRADTI  360
			  	361  YGGSNEIQRNIIAERVLGLPREAKG

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 1 to 120  |  Coverage: 30% Acyl-CoA_dh_N Range: 125 to 177  |  Coverage: 13% Acyl-CoA_dh_M Range: 231 to 377  |  Coverage: 37% Acyl-CoA_dh_1 Range: 2 to 381  |  Coverage: 98% 1 Range: 1 to 385  |  Coverage: 99% 1 Range: 231 to 377  |  Coverage: 37% 2 Range: 114 to 243  |  Coverage: 33% 3 Range: 125 to 177  |  Coverage: 13% 4 Range: 1 to 120  |  Coverage: 30% 5
Number of amino acids : 385
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027711-120
Acyl-CoA_dh_MPF02770125-177
Acyl-CoA_dh_1PF00441231-377
Mtb Structural Proteome models
Model Number1
Model nameRv3560c
Template1JQI    APDBCREDO
Template coverage12_387
Template Identity(%)25.5
Model coverage(%)98.4
Normalized DOPE score-0.476

Structure Models from Chopin
Model Number1
Profile1.20.140.10, 2.40.110.10
Click for model details
zscore40.44
Residue begin1
Residue end385
Model Number2
Profilea.29.3.1
Click for model details
zscore21.34
Residue begin231
Residue end377
Model Number3
Profile2.40.110.10
Click for model details
zscore15.66
Residue begin114
Residue end243
Model Number4
Profilee.6.1.1
Click for model details
zscore12.77
Residue begin125
Residue end177
Model Number5
Profile1.10.540.10
Click for model details
zscore12.73
Residue begin1
Residue end120
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3560cGene nameConfidence Score
Rv3550echA200.985
Rv3552Rv35520.984
Rv3561fadD30.98
Rv3561fadD30.98
Rv3551Rv35510.979
Rv3559cRv3559c0.964
Rv1071cechA90.958
Rv1071cechA90.958
Rv1935cechA130.949
Rv3564fadE330.947
Rv3564fadE330.947
Rv3563fadE320.943
Rv3563fadE320.943
Rv0456cechA20.931
Rv2679echA150.931
Rv0675echA50.93
Rv2831echA160.928
Rv1141cechA110.928
Rv0673echA40.928
Rv1142cechA100.92
Rv0222echA10.919
Rv0971cechA70.919
Rv0632cechA30.919
Rv3516echA190.913
Rv3774echA210.913
Rv0860fadB0.911
Rv0860fadB0.911
Rv0860fadB0.911
Rv3540cltp20.906
Rv3540cltp20.906
Rv2790cltp10.905
Rv2790cltp10.905
Rv1058fadD140.903
Rv1058fadD140.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.902785.55
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
adenosine monophosphatePubChem0.9347.221