Rv3564

Tuberculist information
Gene namefadE33
Protein functionProbable acyl-CoA dehydrogenase FadE33
Functional category(tuberculist)lipid metabolism
Gene location(kb)4005.25
Molecular mass(da)33558.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 318
	  		  	1    MTPPEERQMLRETVASLVAKHAGPAAVRAAMASDRGYDESLWRLLCEQVGAAALVIPEEL   60
			  	61   GGAGGELADAAIVVQELGRALVPSPLLGTTLAELALLAAAKPDAQALTELAQGSAIGALV  120
			  	121  LDPDYVVNGDIADIVVAATSGQLTRWTRFSAQPVATMDPTRRLARLQSEETEPLCPDPGI  180
			  	181  ADTAAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADLYVTIAAARAV  240
			  	241  VADACHAPTPTNAATARLAASEALSTAAAEGIQLHGGIAITWEHDMHLYFKRAHGSAQLL  300
			  	301  ESPREVLRRLESEVWESP

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 4 to 114  |  Coverage: 34% Acyl-CoA_dh_N Range: 180 to 310  |  Coverage: 40% Acyl-CoA_dh_1 Range: 5 to 308  |  Coverage: 95% 1 Range: 1 to 318  |  Coverage: 99% 1 Range: 180 to 310  |  Coverage: 40% 2 Range: 4 to 114  |  Coverage: 34% 3
Number of amino acids : 318
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027714-114
Acyl-CoA_dh_1PF00441180-310
Mtb Structural Proteome models
Model Number1
Model nameRv3564
Template2D29    APDBCREDO
Template coverage10_376
Template Identity(%)32.2
Model coverage(%)95.3
Normalized DOPE score0.306

Structure Models from Chopin
Model Number1
Profilea.29.3.1, e.6.1.1 - 1.10.540.10, 1.20.140.10, 2.40.110.10
Click for model details
zscore35.3
Residue begin1
Residue end318
Model Number2
Profilea.29.3.1
Click for model details
zscore21.92
Residue begin180
Residue end310
Model Number3
Profile1.10.540.10
Click for model details
zscore8.9
Residue begin4
Residue end114
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3564Gene nameConfidence Score
Rv3561fadD30.985
Rv3561fadD30.985
Rv3562fadE310.97
Rv3562fadE310.97
Rv3562fadE310.97
Rv1071cechA90.963
Rv1071cechA90.963
Rv1935cechA130.947
Rv3560cfadE300.947
Rv3560cfadE300.947
Rv3560cfadE300.947
Rv3552Rv35520.942
Rv0456cechA20.94
Rv3551Rv35510.939
Rv2679echA150.937
Rv3550echA200.936
Rv0675echA50.934
Rv0673echA40.931
Rv2831echA160.931
Rv1141cechA110.931
Rv1142cechA100.928
Rv0971cechA70.923
Rv0632cechA30.921
Rv0222echA10.92
Rv3516echA190.917
Rv3774echA210.911
Rv1058fadD140.905
Rv1058fadD140.905
Rv1070cechA80.901
Rv2790cltp10.901
Rv2790cltp10.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine monophosphatePubChem0.9347.221
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
flavin adenine dinucleotidePubChem0.9785.55
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073