Rv2679

Tuberculist information
Gene nameechA15
Protein functionProbable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2995.11
Molecular mass(da)29634.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 276
	  		  	1    MPVTYDDFPSLRCEIHDQPGHEGVLELVLDSPGLNSVGPHMHRDLADIWPVIDRDPAVRV   60
			  	61   VLVRGEGKAFSSGGSFDLIAETIGDYQGRLRIMREARDLVLNLVNFDKPVVSAIRGPAVG  120
			  	121  AGLVVALLADISVAGRAAKIIDGHTKLGVAAGDHAAICWPLLVGMAKAKYYLLTCEPLSG  180
			  	181  EEAERIGLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLNHWYRMFGPAFETSLG  240
			  	241  LEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS

Known structures in the PDB
No Known structures
1 28 55 82 109 136 163 190 217 244 271 Range: 18 to 257  |  Coverage: 86% ECH Range: 1 to 267  |  Coverage: 96% 1 Range: 1 to 276  |  Coverage: 99% 1 Range: 211 to 271  |  Coverage: 21% 2
Number of amino acids : 276
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF0037818-257
Mtb Structural Proteome models
Model Number1
Model nameRv2679
Template1WZ8    APDBCREDO
Template coverage2_264
Template Identity(%)52.1
Model coverage(%)96.4
Normalized DOPE score-1.098

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore33.45
Residue begin1
Residue end276
Model Number2
Profile1.10.12.10
Click for model details
zscore13.34
Residue begin211
Residue end271
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2679Gene nameConfidence Score
Rv3562fadE310.94
Rv1933cfadE180.94
Rv1679fadE160.94
Rv3562fadE310.94
Rv1934cfadE170.94
Rv1679fadE160.94
Rv1934cfadE170.94
Rv1679fadE160.94
Rv1934cfadE170.94
Rv3562fadE310.94
Rv1933cfadE180.94
Rv0231fadE40.937
Rv0131cfadE10.937
Rv0231fadE40.937
Rv0131cfadE10.937
Rv0131cfadE10.937
Rv3564fadE330.937
Rv3564fadE330.937
Rv1467cfadE150.934
Rv0271cfadE60.934
Rv0271cfadE60.934
Rv3505fadE270.934
Rv1467cfadE150.934
Rv0271cfadE60.934
Rv3505fadE270.934
Rv1467cfadE150.934
Rv1467cfadE150.934
Rv1467cfadE150.934
Rv3543cfadE290.931
Rv3563fadE320.931
Rv3560cfadE300.931
Rv3563fadE320.931
Rv3560cfadE300.931
Rv0154cfadE20.931
Rv3543cfadE290.931
Rv3560cfadE300.931
Rv0154cfadE20.931
Rv3543cfadE290.931
Rv0154cfadE20.931
Rv3504fadE260.93
Rv3544cfadE280.93
Rv3504fadE260.93
Rv3544cfadE280.93
Rv3504fadE260.93
Rv0468fadB20.928
Rv0468fadB20.928
Rv2680Rv26800.919
Rv1715fadB30.916
Rv1715fadB30.916
Rv0400cfadE70.913
Rv0400cfadE70.913
Rv0400cfadE70.913
Rv0873fadE100.912
Rv0873fadE100.912
Rv0873fadE100.912
Rv0860fadB0.905
Rv0860fadB0.905
Rv0860fadB0.905
Rv0244cfadE50.902
Rv0244cfadE50.902
Rv0244cfadE50.902
Rv0244cfadE50.902
Rv0244cfadE50.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.901835.608
C05268PubChem0.9881.677
3-hydroxybutyryl-CoAPubChem0.9853.623
C04405PubChem0.9867.65
C0885PubChem0.9917.752
methylcrotonyl CoAPubChem0.9849.635
C16468PubChem0.9875.672
AR-1A9122PubChem0.9787.566
c0887PubChem0.9935.767
flavin adenine dinucleotidePubChem0.9785.55
3-hydroxypropionyl-CoAPubChem0.9839.597
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05271PubChem0.9863.661
deuteriumPubChem0.92.01588
C11945PubChem0.9917.752
C05262PubChem0.9965.836
2-methylbutyryl-CoAPubChem0.9851.651
C01144PubChem0.9853.623
C05273PubChem0.9975.874
NAD+PubChem0.9663.425
protiumPubChem0.92.01576
2-methylacetoacetyl-coenzyme APubChem0.9865.634
C05266PubChem0.9909.73
3-methylcrotonyl-CoAPubChem0.9849.635
methacrylyl-CoAPubChem0.9835.608
C03221PubChem0.9947.821
hydroxyl radicalsPubChem0.917.0073
CHEBI:15477PubChem0.9851.651
NSC112207PubChem0.9785.55
3-hydroxypropionyl-coenzyme APubChem0.9839.597
C05258PubChem0.91021.94
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C16469PubChem0.9893.687
H(+)PubChem0.92.01588
C05275PubChem0.9919.768
1,5-dihydro-FADPubChem0.9787.566
C11947PubChem0.9935.767
C05260PubChem0.9993.889
2-methylacetoacetyl-CoAPubChem0.9865.634
acryloyl-CoAPubChem0.9821.581
trans-2-hexadecenoyl-CoAPubChem0.91003.93
2MCPubChem0.9835.608
C14145PubChem0.9911.659
3-hydroxydecanoyl-CoAPubChem0.9937.783
3-hydroxyadipyl-CoAPubChem0.9911.659
FADH2PubChem0.9787.566
C05276PubChem0.9891.714
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C11946PubChem0.9917.752
alpha-methylbutyryl-CoAPubChem0.9851.651