Rv3562

Tuberculist information
Gene namefadE31
Protein functionProbable acyl-CoA dehydrogenase FadE31
Functional category(tuberculist)lipid metabolism
Gene location(kb)4003.16
Molecular mass(da)41332.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 377
	  		  	1    MDLNFDDETLAFQAEVREFLAANAASIPTKSYDNAEGFAQHRYWDRVLFDAGLSVITWPA   60
			  	61   KYGGRDAPLLHWIVFEEEYFRAGAPGRASANGTSMLAPTLFAHGTAEQLDRILPKMASGE  120
			  	121  QIWAQAWSEPESGSDLASLRSTASKVDGGWLLNGQKIWSSRAPFADMGFGLFRSDPAVER  180
			  	181  HRGLTYFMFDLKAKGVTVRPIAQLGGDTGFGEIFLDDVFVPDRDVIGAPNDGWRAAMSTS  240
			  	241  SNERGMSLRSPARFLASAERLVQLWKDRGSPPEFADRVADAWIKAQAYRLQTFGTVTRLA  300
			  	301  AGGELGAESSVTKVFWSELDVHLHQTALDLRGADGELAGPWTEGLLFALGGPIYAGTNEI  360
			  	361  QRNIIAERLLGLPREKT

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 6 to 120  |  Coverage: 30% Acyl-CoA_dh_N Range: 124 to 175  |  Coverage: 13% Acyl-CoA_dh_M Range: 230 to 370  |  Coverage: 37% Acyl-CoA_dh_1 Range: 3 to 370  |  Coverage: 97% 1 Range: 1 to 377  |  Coverage: 99% 1 Range: 230 to 370  |  Coverage: 37% 2 Range: 113 to 242  |  Coverage: 34% 3 Range: 6 to 120  |  Coverage: 30% 4 Range: 124 to 175  |  Coverage: 13% 5 Range: 1 to 377  |  Coverage: 99% 6
Number of amino acids : 377
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027716-120
Acyl-CoA_dh_MPF02770124-175
Acyl-CoA_dh_1PF00441230-370
Mtb Structural Proteome models
Model Number1
Model nameRv3562
Template2D29    APDBCREDO
Template coverage5_384
Template Identity(%)26.6
Model coverage(%)97.1
Normalized DOPE score-0.199

Structure Models from Chopin
Model Number1
Profile1.20.140.10, 2.40.110.10
Click for model details
zscore39.61
Residue begin1
Residue end377
Model Number2
Profilea.29.3.1
Click for model details
zscore22.72
Residue begin230
Residue end370
Model Number3
Profile2.40.110.10
Click for model details
zscore18.2
Residue begin113
Residue end242
Model Number4
Profile1.10.540.10
Click for model details
zscore12.2
Residue begin6
Residue end120
Model Number5
Profilee.6.1.1
Click for model details
zscore11.26
Residue begin124
Residue end175
Model Number6
Profilee.6.1.1
Click for model details
zscore10.96
Residue begin1
Residue end377
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3562Gene nameConfidence Score
Rv3552Rv35520.983
Rv3550echA200.982
Rv3551Rv35510.981
Rv3563fadE320.972
Rv3563fadE320.972
Rv3564fadE330.97
Rv3564fadE330.97
Rv1935cechA130.959
Rv3561fadD30.947
Rv3561fadD30.947
Rv0456cechA20.942
Rv2679echA150.94
Rv0675echA50.937
Rv1141cechA110.934
Rv0673echA40.934
Rv2831echA160.933
Rv1071cechA90.931
Rv1071cechA90.931
Rv1142cechA100.93
Rv0971cechA70.93
Rv0222echA10.928
Rv0632cechA30.928
Rv3516echA190.918
Rv3774echA210.913
Rv3559cRv3559c0.912
Rv0860fadB0.905
Rv0860fadB0.905
Rv0860fadB0.905
Rv2790cltp10.903
Rv2790cltp10.903
Rv1070cechA80.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
butyryl-CoAPubChem0.9837.624
c1137PubChem0.9875.672
coenzyme APubChem0.9767.534
crotonyl-CoAPubChem0.9835.608
Co-APubChem0.9767.534
phosphatePubChem0.996.9872
[(2S,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[[[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[2-(1-oPubChem0.9833.592
5-methylhex-4-enoyl-CoAPubChem0.9877.688
butyryl phosphatePubChem0.9168.085
3-hydroxybutyryl-CoAPubChem0.9853.623
hydroxyl radicalsPubChem0.917.0073
C16468PubChem0.9875.672