Rv1071c

Tuberculist information
Gene nameechA9
Protein functionPossible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1195.06
Molecular mass(da)36322
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 345
	  		  	1    VTGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLATVLMSWEHEDAVHAVVLSGAG   60
			  	61   ERGLCAGGDVVAVYHSARKDGVEARRFWRHEYLLNALIGRFAKPYVALMDGIVMGGGVGV  120
			  	121  SAHANTRVVTDTSKVAMPEVGIGFIPDVGGVYLLSRAPGALGLHAALTGAPFSGADAIAL  180
			  	181  GFADHFVPHGDLDAFTQKIVTGGVESALAAHAVEPPPSTLAAQRDWIDECYAGDSVADIV  240
			  	241  AALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDTLEDVLIQDYRVSSASLRSH  300
			  	301  DLVEGIRAQLIDKDRNPNWSPATLDAITAADIEAYFEPVDDDLSF

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 9 to 311  |  Coverage: 87% ECH Range: 219 to 337  |  Coverage: 34% ECH_C Range: 1 to 345  |  Coverage: 99% 1 Range: 9 to 311  |  Coverage: 87% 1
Number of amino acids : 345
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF003789-311
ECH_CPF13766219-337
Mtb Structural Proteome models
Model Number1
Model nameRv1071c
Template1WDK    APDBCREDO
Template coverage1_407
Template Identity(%)18.8
Model coverage(%)99.7
Normalized DOPE score0.482

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore23.93
Residue begin9
Residue end311
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1071cGene nameConfidence Score
Rv0751cmmsB0.992
Rv0751cmmsB0.992
Rv0752cfadE90.973
Rv0752cfadE90.973
Rv0752cfadE90.973
Rv3274cfadE250.966
Rv3274cfadE250.966
Rv3274cfadE250.966
Rv3564fadE330.963
Rv3564fadE330.963
Rv0468fadB20.962
Rv0468fadB20.962
Rv3560cfadE300.958
Rv3563fadE320.958
Rv3560cfadE300.958
Rv3563fadE320.958
Rv3560cfadE300.958
Rv3543cfadE290.957
Rv3543cfadE290.957
Rv3543cfadE290.957
Rv0860fadB0.956
Rv1467cfadE150.956
Rv1467cfadE150.956
Rv1467cfadE150.956
Rv0860fadB0.956
Rv1467cfadE150.956
Rv0860fadB0.956
Rv1467cfadE150.956
Rv1715fadB30.952
Rv1715fadB30.952
Rv3544cfadE280.95
Rv3544cfadE280.95
Rv1550fadD110.949
Rv0244cfadE50.947
Rv0244cfadE50.947
Rv0244cfadE50.947
Rv0244cfadE50.947
Rv0244cfadE50.947
Rv1679fadE160.941
Rv1679fadE160.941
Rv1679fadE160.941
Rv2502caccD10.933
Rv0154cfadE20.932
Rv0154cfadE20.932
Rv0154cfadE20.932
Rv2724cfadE200.931
Rv1933cfadE180.931
Rv2724cfadE200.931
Rv1933cfadE180.931
Rv3562fadE310.931
Rv2724cfadE200.931
Rv1934cfadE170.931
Rv3562fadE310.931
Rv1934cfadE170.931
Rv3562fadE310.931
Rv1934cfadE170.931
Rv0131cfadE10.93
Rv0131cfadE10.93
Rv0131cfadE10.93
Rv0231fadE40.93
Rv0231fadE40.93
Rv0271cfadE60.928
Rv3505fadE270.928
Rv0271cfadE60.928
Rv3505fadE270.928
Rv0271cfadE60.928
Rv0975cfadE130.924
Rv0975cfadE130.924
Rv0975cfadE130.924
Rv0215cfadE30.922
Rv0400cfadE70.922
Rv0215cfadE30.922
Rv0400cfadE70.922
Rv0215cfadE30.922
Rv0400cfadE70.922
Rv3504fadE260.92
Rv3504fadE260.92
Rv3504fadE260.92
Rv1070cechA80.91
Rv2789cfadE210.908
Rv2789cfadE210.908
Rv2789cfadE210.908
Rv0972cfadE120.907
Rv0972cfadE120.907
Rv0972cfadE120.907
Rv3140fadE230.903
Rv3140fadE230.903
Rv3139fadE240.902
Rv3139fadE240.902
Rv3139fadE240.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
3-hydroxyisobutyratePubChem0.973104.105
2MCPubChem0.957835.608
methacrylyl-CoAPubChem0.956835.608
3-hydroxypropionyl-CoAPubChem0.953839.597
3-hydroxypropionyl-coenzyme APubChem0.952839.597
3-hydroxy-2-methylpropionyl-CoAPubChem0.941853.623
coenzyme APubChem0.924767.534
deuteriumPubChem0.9042.01588
alpha-methylbutyryl-CoAPubChem0.9851.651
C05268PubChem0.9881.677
crotonyl-CoAPubChem0.9835.608
C14145PubChem0.9911.659
C0885PubChem0.9917.752
2-methylbutyryl-CoAPubChem0.9851.651
FADH2PubChem0.9787.566
c0887PubChem0.9935.767
1,5-dihydro-FADPubChem0.9787.566
C11946PubChem0.9917.752
AR-1A9122PubChem0.9787.566
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
C04405PubChem0.9867.65
C05271PubChem0.9863.661
CHEBI:28259PubChem0.9853.623
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05262PubChem0.9965.836
3-methylcrotonyl-CoAPubChem0.9849.635
C05273PubChem0.9975.874
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C16469PubChem0.9893.687
2-methylacetoacetyl-coenzyme APubChem0.9865.634
C05266PubChem0.9909.73
3-hydroxybutyryl-CoAPubChem0.9853.623
C11945PubChem0.9917.752
C03221PubChem0.9947.821
methylcrotonyl CoAPubChem0.9849.635
2-methylacetoacetyl-CoAPubChem0.9865.634
C01144PubChem0.9853.623
NSC112207PubChem0.9785.55
flavin adenine dinucleotidePubChem0.9785.55
protiumPubChem0.92.01576
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C05275PubChem0.9919.768
CHEBI:15477PubChem0.9851.651
H(+)PubChem0.92.01588
C05260PubChem0.9993.889
3-hydroxyadipyl-CoAPubChem0.9911.659
C05258PubChem0.91021.94
trans-2-hexadecenoyl-CoAPubChem0.91003.93
NAD+PubChem0.9663.425
C16468PubChem0.9875.672
Co-APubChem0.9767.534
3-hydroxydecanoyl-CoAPubChem0.9937.783
C11947PubChem0.9935.767
C05276PubChem0.9891.714
hydroxyl radicalsPubChem0.917.0073
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
acryloyl-CoAPubChem0.9821.581
selenomethioninePubChem0.738196.106
SeMetPubChem0.738196.106