Rv2789c

Tuberculist information
Gene namefadE21
Protein functionProbable acyl-CoA dehydrogenase FadE21
Functional category(tuberculist)lipid metabolism
Gene location(kb)3097.71
Molecular mass(da)44743.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 410
	  		  	1    MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFGLDVLLAESVNQ   60
			  	61   MLDGERAKREKRDSSGSFGLADQASMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRG  120
			  	121  TLAQQERWVPTLVTLEKIAAWAITEPDSGSDAFGGMKTHVTRDGEDYILNGHKTFITNGP  180
			  	181  YADVLVVYAKLADGEPASDWRNRPVLVFVLDAGMPGLTQGKPFKKMGMMSSPTGELFFDN  240
			  	241  VRLTPDRLLCAEGDGRDSARANFAVERLGVALMSLGIINECHRLCVDYAKTRTLWGRNIG  300
			  	301  QFQLIQLKLAKMEVARINVQNMVFQAIERLKAGKQLTLAEASAIKLYSSEAATDVAMEAV  360
			  	361  QLFGGNGYMAEYRVEQLARDAKSLMIYAGSNEVQVTHIAKGLLGEPASRA

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 5 to 136  |  Coverage: 31% Acyl-CoA_dh_N Range: 140 to 193  |  Coverage: 12% Acyl-CoA_dh_M Range: 253 to 403  |  Coverage: 36% Acyl-CoA_dh_1 Range: 2 to 404  |  Coverage: 98% 1 Range: 1 to 410  |  Coverage: 99% 1 Range: 251 to 410  |  Coverage: 38% 2 Range: 1 to 256  |  Coverage: 62% 3 Range: 128 to 265  |  Coverage: 33% 4 Range: 5 to 136  |  Coverage: 31% 5 Range: 5 to 374  |  Coverage: 90% 6
Number of amino acids : 410
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027715-136
Acyl-CoA_dh_MPF02770140-193
Acyl-CoA_dh_1PF00441253-403
Mtb Structural Proteome models
Model Number1
Model nameRv2789c
Template1BUC    APDBCREDO
Template coverage3_383
Template Identity(%)34.1
Model coverage(%)98.0
Normalized DOPE score-0.541

Structure Models from Chopin
Model Number1
Profile1.20.140.10, 2.40.110.10
Click for model details
zscore60.22
Residue begin1
Residue end410
Model Number2
Profilea.29.3.1
Click for model details
zscore34.44
Residue begin251
Residue end410
Model Number3
Profilee.6.1.1
Click for model details
zscore19.28
Residue begin1
Residue end256
Model Number4
Profile2.40.110.10
Click for model details
zscore17.5
Residue begin128
Residue end265
Model Number5
Profile1.10.540.10
Click for model details
zscore12.47
Residue begin5
Residue end136
Model Number6
Profilee.6.1.2
Click for model details
zscore8.44
Residue begin5
Residue end374
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2789cGene nameConfidence Score
Rv3774echA210.978
Rv2790cltp10.976
Rv2790cltp10.976
Rv0860fadB0.911
Rv0860fadB0.911
Rv0860fadB0.911
Rv3551Rv35510.91
Rv0971cechA70.91
Rv3552Rv35520.91
Rv1071cechA90.908
Rv1071cechA90.908
Rv1070cechA80.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.934785.55
isovaleryl-CoAPubChem0.912851.651
3-methylcrotonyl-CoAPubChem0.901849.635
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
3-methylbutyryl-CoAPubChem0.9851.651
c1137PubChem0.9875.672
C16468PubChem0.9875.672
5-methylhex-4-enoyl-CoAPubChem0.9877.688
CHEBI:15486PubChem0.9849.635
1,5-dihydro-FADPubChem0.9787.566