Rv2790c

Tuberculist information
Gene nameltp1
Protein functionProbable lipid-transfer protein Ltp1
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)3098.96
Molecular mass(da)42904.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 401
	  		  	1    MPNQGSSNKVYVIGVGMTKFEKPGRREGWDYPDMARESGTKALRDAGIDYREVEQGYVGY   60
			  	61   VYGESTSGQRALYELGMTGIPIVNVNNNCSTGSTALYLGAQAIRGGLADCVLALGFEKMQ  120
			  	121  PGALGGGADDRESPLGRHVKALAEIDEFGFPVAPWMFGAAGREHMKKYGTTAEHFAKIGY  180
			  	181  KNHKHSVNNPYAQFQDEYTLDDILASKMISDPLTKLQCSPTSDGSAAVVLASEDYLANHN  240
			  	241  LAGRAVEIVGQAMTTDFASTFDGSARNIIGYDMTVQAAQRVYQQSGLGPKDFGVIELHDC  300
			  	301  FSANELLLYEALGLCGPGEAPELIDDNQTTYGGRWVVNPSGGLISKGHPLGATGLAQCAE  360
			  	361  LTWQLRGTAEARQVDNVTAALQHNIGLGGAAVVTAYQRAER

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 8 to 234  |  Coverage: 56% Thiolase_N Range: 258 to 395  |  Coverage: 34% Thiolase_C Range: 6 to 399  |  Coverage: 98% 1 Range: 15 to 142  |  Coverage: 31% 1
Number of amino acids : 401
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_NPF001088-234
Thiolase_CPF02803258-395
Mtb Structural Proteome models
Model Number1
Model nameRv2790c
Template1WDK    CPDBCREDO
Template coverage4_391
Template Identity(%)21.4
Model coverage(%)98.0
Normalized DOPE score0.272

Structure Models from Chopin
Model Number1
Profilec.95.1.1
Click for model details
zscore9.89
Residue begin15
Residue end142
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2790cGene nameConfidence Score
Rv2789cfadE210.976
Rv2789cfadE210.976
Rv2789cfadE210.976
Rv0148Rv01480.94
Rv0148Rv01480.94
Rv3274cfadE250.939
Rv3274cfadE250.939
Rv3274cfadE250.939
Rv3389chtdY0.936
Rv3389chtdY0.936
Rv2724cfadE200.934
Rv3538Rv35380.934
Rv2724cfadE200.934
Rv3538Rv35380.934
Rv2724cfadE200.934
Rv0154cfadE20.933
Rv0154cfadE20.933
Rv0154cfadE20.933
Rv1323fadA40.933
Rv1323fadA40.933
Rv1074cfadA30.93
Rv1074cfadA30.93
Rv0752cfadE90.929
Rv0752cfadE90.929
Rv0752cfadE90.929
Rv0975cfadE130.928
Rv0975cfadE130.928
Rv0975cfadE130.928
Rv3556cfadA60.927
Rv3556cfadA60.927
Rv0859fadA0.926
Rv0859fadA0.926
Rv3546fadA50.925
Rv3546fadA50.925
Rv0860fadB0.924
Rv3523ltp30.924
Rv0215cfadE30.924
Rv0215cfadE30.924
Rv0860fadB0.924
Rv0215cfadE30.924
Rv0860fadB0.924
Rv0243fadA20.92
Rv0914cRv0914c0.92
Rv0914cRv0914c0.92
Rv0243fadA20.92
Rv1867Rv18670.915
Rv0972cfadE120.915
Rv0972cfadE120.915
Rv0972cfadE120.915
Rv0753cmmsA0.914
Rv3280accD50.909
Rv0131cfadE10.906
Rv0131cfadE10.906
Rv0131cfadE10.906
Rv1934cfadE170.905
Rv1934cfadE170.905
Rv3560cfadE300.905
Rv1934cfadE170.905
Rv3560cfadE300.905
Rv3560cfadE300.905
Rv3140fadE230.904
Rv3140fadE230.904
Rv3562fadE310.903
Rv0271cfadE60.903
Rv3562fadE310.903
Rv0271cfadE60.903
Rv3562fadE310.903
Rv0271cfadE60.903
Rv2605ctesB20.903
Rv1933cfadE180.902
Rv1933cfadE180.902
Rv3504fadE260.901
Rv3504fadE260.901
Rv3543cfadE290.901
Rv3564fadE330.901
Rv3504fadE260.901
Rv3543cfadE290.901
Rv3564fadE330.901
Rv3505fadE270.901
Rv3543cfadE290.901
Rv3505fadE270.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
choloyl-CoAPubChem0.9291158.09
coenzyme APubChem0.926767.534
acetyl-CoAPubChem0.92809.571
propionyl-CoAPubChem0.913823.597
lauroyl-CoAPubChem0.9949.837
C16471PubChem0.9891.671
Chebi:28726PubChem0.9991.873
C05263PubChem0.9963.82
CHEBI:28533PubChem0.91198.15
c1139PubChem0.9891.671
succinyl-CoAPubChem0.9867.607
propionyl-coenzyme APubChem0.9823.597
3-oxooctanoyl-CoAPubChem0.9907.714
3-methylcrotonyl-CoAPubChem0.9849.635
hexanoyl-CoAPubChem0.9865.677
cholyl-coenzyme APubChem0.91158.09
C05449PubChem0.91198.15
butyryl-CoAPubChem0.9837.624
decanoyl-CoAPubChem0.9921.783
CHEBI:28701PubChem0.91142.09
C05467PubChem0.91214.15
octanoyl-CoAPubChem0.9893.73
beta-ketopalmitoyl-CoAPubChem0.91019.93
CHEBI:27379PubChem0.91214.15
5-methylhex-4-enoyl-CoAPubChem0.9877.688
Co-APubChem0.9767.534
C05265PubChem0.9935.767
2-methylacetoacetyl-CoAPubChem0.9865.634
myristoyl-CoAPubChem0.9977.89
3-oxohexadecanoyl-CoAPubChem0.91019.93
3-ketohexanoyl-CoAPubChem0.9879.661
benzoyl-CoAPubChem0.9871.64
C05261PubChem0.9991.873
chenodeoxycholoyl-CoAPubChem0.91142.09