Rv3538

Tuberculist information
Gene nameRv3538
Protein functionProbable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase.
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3977.06
Molecular mass(da)30216.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 286
	  		  	1    MPIDLDVALGAQLPPVEFSWTSTDVQLYQLGLGAGSDPMNPRELSYLADDTPQVLPTFGN   60
			  	61   VAATFHLTTPPTVQFPGIDIELSKVLHASERVEVPAPLPPSGSARAVTRFTDIWDKGKAA  120
			  	121  VICSETTATTPDGLLLWTQKRSIYARGEGGFGGKRGPSGSDVAPERAPDLQVAMPILPQQ  180
			  	181  ALLYRLCGDRNPLHSDPEFAAAAGFPRPILHGLCTYGMTCKAIVDALLDSDATAVAGYGA  240
			  	241  RFAGVAYPGETLTVNVWKDGRRLVASVVAPTRDNAVVLSGVELVPA

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 7 to 139  |  Coverage: 46% zf-MaoC Range: 160 to 278  |  Coverage: 41% MaoC_dehydratas Range: 8 to 285  |  Coverage: 96% 1
Number of amino acids : 286
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
zf-MaoCPF134527-139
MaoC_dehydratasPF01575160-278
Mtb Structural Proteome models
Model Number1
Model nameRv3538
Template1S9C    APDBCREDO
Template coverage10_289
Template Identity(%)31.5
Model coverage(%)96.9
Normalized DOPE score-0.151

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3538Gene nameConfidence Score
Rv3537kstD0.976
Rv0148Rv01480.975
Rv0148Rv01480.975
Rv2790cltp10.934
Rv2790cltp10.934
Rv3389chtdY0.924
Rv3389chtdY0.924
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions