Rv0148

Tuberculist information
Gene nameRv0148
Protein functionProbable short-chain type dehydrogenase/reductase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)174.833
Molecular mass(da)29778.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 286
	  		  	1    MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDGTGAGSAMADEVVAEIR   60
			  	61   DKGGRAVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGILRDGTFHKMSFENWDAVL  120
			  	121  KVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGLFGNFGQTNYGAAKLGLVGLINTLAL  180
			  	181  EGAKYNIHANALAPIAATRMTQDILPPEVLEKLTPEFVAPVVAYLCTEECADNASVYVVG  240
			  	241  GGKVQRVALFGNDGANFDKPPSVQDVAARWAEITDLSGAKIAGFKL

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 7 to 183  |  Coverage: 61% adh_short Range: 9 to 275  |  Coverage: 93% Polysacc_synt_2 Range: 7 to 279  |  Coverage: 95% 1 Range: 1 to 286  |  Coverage: 99% 1
Number of amino acids : 286
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
adh_shortPF001067-183
Polysacc_synt_2PF027199-275
Mtb Structural Proteome models
Model Number1
Model nameRv0148
Template1GZ6    APDBCREDO
Template coverage10_282
Template Identity(%)52.0
Model coverage(%)95.1
Normalized DOPE score-0.468

Structure Models from Chopin
Model Number1
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore18.48
Residue begin1
Residue end286
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0148Gene nameConfidence Score
Rv3538Rv35380.975
Rv3538Rv35380.975
Rv3389chtdY0.965
Rv3389chtdY0.965
Rv2790cltp10.94
Rv2790cltp10.94
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions