Rv3389c

Tuberculist information
Gene namehtdY
Protein functionProbable 3-hydroxyacyl-thioester dehydratase HtdY
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3803.92
Molecular mass(da)30296.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 290
	  		  	1    MAIDPNSIGAVTEPMLFEWTDRDTLLYAIGVGAGTGDLAFTTENSHGIDQQVLPTYAVIC   60
			  	61   CPAFGAAAKVGTFNPAALLHGSQGIRLHAPLPAAGKLSVVTEVADIQDKGEGKNAIVVLR  120
			  	121  GRGCDPESGSLVAETLTTLVLRGQGGFGGARGERPAAPEFPDRHPDARIDMPTREDQALI  180
			  	181  YRLSGDRNPLHSDPWFATQLAGFPKPILHGLCTYGVAGRALVAELGGGVAANITSIAARF  240
			  	241  TKPVFPGETLSTVIWRTEPGRAVFRTEVAGSDGAEARVVLDDGAVEYVAG

Known structures in the PDB
No Known structures
1 30 59 88 117 146 175 204 233 262 291 Range: 6 to 135  |  Coverage: 44% zf-MaoC Range: 157 to 278  |  Coverage: 41% MaoC_dehydratas Range: to 2  |  Coverage: 0% 1 Range: 7 to 288  |  Coverage: 96% 2
Number of amino acids : 290
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
zf-MaoCPF134526-135
MaoC_dehydratasPF01575157-278
Mtb Structural Proteome models
Model Number1
Model nameRv3389c_3khp_A
Template3KHP    APDBCREDO
Template coverage0_289
Template Identity(%)100.0
Model coverage(%)99.7
Normalized DOPE score-1.182

Model Number2
Model nameRv3389c
Template1S9C    APDBCREDO
Template coverage10_289
Template Identity(%)39.1
Model coverage(%)96.9
Normalized DOPE score-0.106

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3389cGene nameConfidence Score
Rv0148Rv01480.965
Rv0148Rv01480.965
Rv2790cltp10.936
Rv2790cltp10.936
Rv3538Rv35380.924
Rv3538Rv35380.924
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
tartratePubChem0.9150.087
chloridePubChem0.935.453
L-tartratePubChem0.9148.071