Rv3537

Tuberculist information
Gene namekstD
Protein functionProbable dehydrogenase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3975.37
Molecular mass(da)60636
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 563
	  		  	1    MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTARSGGGVWIPNNEVLK   60
			  	61   RRGVRDTPEAARTYLHGIVGEIVEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYY  120
			  	121  PEAPGGRPGGRSIEPKPFNARKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRG  180
			  	181  VLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVS  240
			  	241  GVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEWTVGASANTGD  300
			  	301  GILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPGSIIVNMSGKRFMNESMPYV  360
			  	361  EACHHMYGGEHGQGPGPGENIPAWLVFDQRYRDRYIFAGLQPGQRIPSRWLDSGVIVQAD  420
			  	421  TLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEV  480
			  	481  GHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGG  540
			  	541  TIGPAMTFGYLAALHIADQAGKR

Known structures in the PDB
No Known structures
1 57 113 169 225 281 337 393 449 505 561 Range: 7 to 542  |  Coverage: 95% FAD_binding_2 Range: 8 to 560  |  Coverage: 98% 1 Range: 1 to 562  |  Coverage: 99% 1 Range: 316 to 497  |  Coverage: 32% 2 Range: 4 to 211  |  Coverage: 36% 3
Number of amino acids : 563
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FAD_binding_2PF008907-542
Mtb Structural Proteome models
Model Number1
Model nameRv3537
Template1QO8    APDBCREDO
Template coverage124_563
Template Identity(%)31.1
Model coverage(%)97.9
Normalized DOPE score0.583

Structure Models from Chopin
Model Number1
Profilea.138.1.3, d.168.1.1 - 1.10.1130.10, 3.50.50.60, 3.90.700.10
Click for model details
zscore42.39
Residue begin1
Residue end562
Model Number2
Profile3.90.700.10
Click for model details
zscore21.95
Residue begin316
Residue end497
Model Number3
Profilec.3.1.7
Click for model details
zscore10.52
Residue begin4
Residue end211
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3537Gene nameConfidence Score
Rv3538Rv35380.976
Rv3538Rv35380.976
Rv3526kshA0.923
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions