Rv3526

Tuberculist information
Gene namekshA
Protein functionOxygenase component of 3-ketosteroid-9-alpha-hydroxylase KshA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3962.44
Molecular mass(da)44235.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 386
	  		  	1    VSTDTSGVGVREIDAGALPTRYARGWHCLGVAKDYLEGKPHGVEAFGTKLVVFADSHGDL   60
			  	61   KVLDGYCRHMGGDLSEGTVKGDEVACPFHDWRWGGDGRCKLVPYARRTPRMARTRSWTTD  120
			  	121  VRSGLLFVWHDHEGNPPDPAVRIPEIPEAASDEWTDWRWNRILIEGSNCRDIIDNVTDMA  180
			  	181  HFFYIHFGLPTYFKNVFEGHIASQYLHNVGRPDVDDLGTSYGEAHLDSEASYFGPSFMIN  240
			  	241  WLHNRYGNYKSESILINCHYPVTQNSFVLQWGVIVEKPKGMSEEMTDKLSRVFTEGVSKG  300
			  	301  FLQDVEIWKHKTRIDNPLLVEEDGAVYQLRRWYEQFYVDVADIKPEMVERFEIEVDTKRA  360
			  	361  NEFWNAEVEKNLKSREVSDDVPAEQH

Known structures in the PDB
PDB ID2ZYL
Total residue count386
Number of chains1
MethodX-RAY
Resolution2.3
PDB ID4QCK
Total residue count386
Number of chains1
MethodX-RAY
Resolution2.46
1 39 77 115 153 191 229 267 305 343 381 Range: 25 to 118  |  Coverage: 24% Rieske Range: 14 to 374  |  Coverage: 93% 1 Range: 22 to 335  |  Coverage: 81% 2 Range: 19 to 158  |  Coverage: 36% 1
Number of amino acids : 386
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
RieskePF0035525-118
Mtb Structural Proteome models
Model Number1
Model nameRv3526_2zyl_A
Template2ZYL    APDBCREDO
Template coverage14_374
Template Identity(%)100.0
Model coverage(%)93.3
Normalized DOPE score-1.076

Model Number2
Model nameRv3526
Template1WW9    APDBCREDO
Template coverage25_371
Template Identity(%)22.0
Model coverage(%)81.1
Normalized DOPE score0.342

Structure Models from Chopin
Model Number1
Profile2.102.10.10
Click for model details
zscore13.95
Residue begin19
Residue end158
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3526Gene nameConfidence Score
Rv3571kshB0.949
Rv3571kshB0.949
Rv3571kshB0.949
Rv3537kstD0.923
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
Fe(III)PubChem0.955.845
Na(+)PubChem0.922.9898