Rv3571

Tuberculist information
Gene namekshB
Protein functionReductase component of 3-ketosteroid-9-alpha-hydroxylase KshB
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4012.42
Molecular mass(da)38247.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 358
	  		  	1    LTEAIGDEPLGDHVLELQIAEVVDETDEARSLVFAVPDGSDDPEIPPRRLRYAPGQFLTL   60
			  	61   RVPSERTGSVARCYSLCSSPYTDDALAVTVKRTADGYASNWLCDHAQVGMRIHVLAPSGN  120
			  	121  FVPTTLDADFLLLAAGSGITPIMSICKSALAEGGGQVTLLYANRDDRSVIFGDALRELAA  180
			  	181  KYPDRLTVLHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVPAQ  240
			  	241  QVHIEVFKSLESDPFAAVKVDDSGDEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLD  300
			  	301  APFSCREGHCGACACTLRAGKVNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 16 to 122  |  Coverage: 29% FAD_binding_6 Range: 132 to 230  |  Coverage: 27% NAD_binding_1 Range: 273 to 348  |  Coverage: 20% Fer2 Range: 9 to 355  |  Coverage: 96% 1 Range: 5 to 253  |  Coverage: 69% 1 Range: 122 to 254  |  Coverage: 36% 2 Range: 264 to 358  |  Coverage: 26% 3 Range: 1 to 129  |  Coverage: 35% 4 Range: 1 to 350  |  Coverage: 97% 5 Range: 102 to 285  |  Coverage: 51% 6
Number of amino acids : 358
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FAD_binding_6PF0097016-122
NAD_binding_1PF00175132-230
Fer2PF00111273-348
Mtb Structural Proteome models
Model Number1
Model nameRv3571
Template2PIA    APDBCREDO
Template coverage3_320
Template Identity(%)24.8
Model coverage(%)96.6
Normalized DOPE score0.124

Structure Models from Chopin
Model Number1
Profileb.43.4.2, c.25.1.2 - 2.40.30.10, 3.40.50.80
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zscore26.67
Residue begin5
Residue end253
Model Number2
Profilec.25.1.5
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zscore19.62
Residue begin122
Residue end254
Model Number3
Profiled.15.4.2 - 3.10.20.30
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zscore19.21
Residue begin264
Residue end358
Model Number4
Profileb.43.4.2
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zscore17.76
Residue begin1
Residue end129
Model Number5
Profileb.43.4.2, c.25.1.1 - 2.40.30.10, 3.40.50.80
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zscore16.86
Residue begin1
Residue end350
Model Number6
Profile3.40.50.80
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zscore12.72
Residue begin102
Residue end285
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3571Gene nameConfidence Score
Rv3570chsaA0.974
Rv3570chsaA0.974
Rv3526kshA0.949
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions