Rv2605c

Tuberculist information
Gene nametesB2
Protein functionProbable acyl-CoA thioesterase II TesB2 (TEII)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2932.3
Molecular mass(da)31536.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 281
	  		  	1    VSIEEILDLEQLEVNIYRGSVFSPESGFLQRTFGGHVAGQSLVSAVRTVDPRYMVHSLHG   60
			  	61   YFLRPGDAKERTVFLVERIRDGGSFCTRRVNAVQHGETIFSMAASFQTEQEGITHQDVMP  120
			  	121  AAPPPDGLPGLNSIKVFDDAGFRQFDEWDVCIVPRERLRLLPGKASQQQVWLRHRDPLPD  180
			  	181  DPVLHICALAYMSDLTLLGSAQVNHLDVRDQLQVASLDHAMWFMRPFRADEWLLYDQSSP  240
			  	241  SASGGRALTRGEIFTRSGEMVAAVMQEGLTRHRRGHRSVGQ

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 12 to 113  |  Coverage: 35% Acyl_CoA_thio Range: 139 to 269  |  Coverage: 46% Acyl_CoA_thio Range: 6 to 272  |  Coverage: 94% 1 Range: 5 to 108  |  Coverage: 36% 1
Number of amino acids : 281
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl_CoA_thioPF0255112-113
Acyl_CoA_thioPF02551139-269
Mtb Structural Proteome models
Model Number1
Model nameRv2605c
Template1C8U    APDBCREDO
Template coverage11_284
Template Identity(%)43.8
Model coverage(%)94.7
Normalized DOPE score-0.278

Structure Models from Chopin
Model Number1
Profiled.38.1.3 - 3.10.129.10
Click for model details
zscore33.44
Residue begin5
Residue end108
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2605cGene nameConfidence Score
Rv2604csnoP0.934
Rv2603cRv2603c0.921
Rv2606csnzP0.909
Rv2790cltp10.903
Rv2790cltp10.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
coenzyme APubChem0.944767.534
choloyl-CoAPubChem0.9351158.09
formatePubChem0.91745.0174
bile acidPubChem0.914408.571
hydroxyl radicalsPubChem0.917.0073
acetatePubChem0.959.044
Co-APubChem0.9767.534
AcCoAPubChem0.9809.571
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
acetyl-CoAPubChem0.9809.571
H(+)PubChem0.92.01588
cholic acidPubChem0.9408.571
cholyl-coenzyme APubChem0.91158.09