Rv2606c

Tuberculist information
Gene namesnzP
Protein functionPossible pyridoxine biosynthesis protein SnzP
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2933.17
Molecular mass(da)31365.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 299
	  		  	1    MDPAGNPATGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAVMALERVPADIRAQ   60
			  	61   GGVSRMSDPDMIEGIIAAVTIPVMAKVRIGHFVEAQILQTLGVDYIDESEVLTPADYAHH  120
			  	121  IDKWNFTVPFVCGATNLGEALRRISEGAAMIRSKGEAGTGDVSNATTHMRAIGGEIRRLT  180
			  	181  SMSEDELFVAAKELQAPYELVAEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVG  240
			  	241  SGIFKSGAPEHRAAAIVKATTFFDDPDVLAKVSRGLGEAMVGINVDEIAVGHRLAQRGW

Known structures in the PDB
PDB ID4JDY
Total residue count792
Number of chains3
MethodX-RAY
Resolution1.8
1 30 59 88 117 146 175 204 233 262 291 Range: 9 to 217  |  Coverage: 69% SOR_SNZ Range: 23 to 276  |  Coverage: 84% 1 Range: 23 to 276  |  Coverage: 84% 1
Number of amino acids : 299
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SOR_SNZPF016809-217
Mtb Structural Proteome models
Model Number1
Model nameRv2606c
Template1ZNN    APDBCREDO
Template coverage18_271
Template Identity(%)63.7
Model coverage(%)84.6
Normalized DOPE score-0.695

Structure Models from Chopin
Model Number1
Profilec.1.2.6
Click for model details
zscore30.37
Residue begin23
Residue end276
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2606cGene nameConfidence Score
Rv2604csnoP0.999
Rv2607pdxH0.987
Rv2607pdxH0.987
Rv2603cRv2603c0.971
Rv2605ctesB20.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ribulose 5-phosphatePubChem0.989230.11
pyridoxal phosphatePubChem0.983247.142
ribulose-5-phosphatePubChem0.97230.11
D-glyceraldehyde-3-phosphatePubChem0.957170.058
vitamin B6PubChem0.834169.178
phosphatePubChem0.78896.9872
hydron diphosphatePubChem0.712391.981
2-methyl-2,4-pentanediolPubChem0.71118.174
(4s)-2-Methyl-2,4-PentanediolPubChem0.71118.174
ethylene glycol; hydronPubChem0.70763.0758
chloridePubChem0.70735.453
polyglutaminePubChem0.707146.145
magnesiumPubChem0.70724.305
polyethylene glycolPubChem0.70762.0678