Rv3504

Tuberculist information
Gene namefadE26
Protein functionProbable acyl-CoA dehydrogenase FadE26
Functional category(tuberculist)lipid metabolism
Gene location(kb)3922.47
Molecular mass(da)43784.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 400
	  		  	1    MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYGVGNVYRETIAQMGRDGWLAL   60
			  	61   GWPKEYGGQGRSAMDQLIFTDEAAIAGAPVPFLTINSVAPTIMAYGTDEQKRFFLPRIAA  120
			  	121  GDLHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVNGQKMWTSLIQYADYVWLAVRTNPES  180
			  	181  SGAKKHRGISVLIVPTTAEGFSWTPVHTMAGPDTSATYYSDVRVPVANRVGEENAGWKLV  240
			  	241  TNQLNHERVALVSPAPIFGCLREVREWAQNTKDAGGTRLIDSEWVQLNLARVHAKAEVLK  300
			  	301  LINWELASSQSGPKDAGPSPADASAAKVFGTELATEAYRLLMEVLGTAATLRQNSPGALL  360
			  	361  RGRVERMHRACLILTFGGGTNEVQRDIIGMVALGLPRANR

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 6 to 122  |  Coverage: 28% Acyl-CoA_dh_N Range: 126 to 177  |  Coverage: 12% Acyl-CoA_dh_M Range: 234 to 393  |  Coverage: 39% Acyl-CoA_dh_1 Range: 8 to 388  |  Coverage: 95% 1 Range: 1 to 400  |  Coverage: 99% 1 Range: 234 to 393  |  Coverage: 39% 2 Range: 115 to 246  |  Coverage: 32% 3 Range: 6 to 122  |  Coverage: 28% 4 Range: 126 to 177  |  Coverage: 12% 5 Range: 1 to 237  |  Coverage: 59% 6
Number of amino acids : 400
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027716-122
Acyl-CoA_dh_MPF02770126-177
Acyl-CoA_dh_1PF00441234-393
Mtb Structural Proteome models
Model Number1
Model nameRv3504
Template1RX0    APDBCREDO
Template coverage22_386
Template Identity(%)29.6
Model coverage(%)95.0
Normalized DOPE score-0.663

Structure Models from Chopin
Model Number1
Profile1.20.140.10, 2.40.110.10
Click for model details
zscore41.03
Residue begin1
Residue end400
Model Number2
Profilea.29.3.1
Click for model details
zscore22.79
Residue begin234
Residue end393
Model Number3
Profile2.40.110.10
Click for model details
zscore15.61
Residue begin115
Residue end246
Model Number4
Profile1.10.540.10
Click for model details
zscore14.06
Residue begin6
Residue end122
Model Number5
Profilee.6.1.1
Click for model details
zscore12.7
Residue begin126
Residue end177
Model Number6
Profilee.6.1.1
Click for model details
zscore10.53
Residue begin1
Residue end237
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3504Gene nameConfidence Score
Rv3550echA200.959
Rv3516echA190.957
Rv3505fadE270.939
Rv3505fadE270.939
Rv0456cechA20.93
Rv2679echA150.93
Rv0675echA50.928
Rv3506fadD170.926
Rv3506fadD170.926
Rv1935cechA130.925
Rv1071cechA90.92
Rv2831echA160.92
Rv1141cechA110.92
Rv0673echA40.92
Rv1071cechA90.92
Rv1142cechA100.919
Rv0222echA10.917
Rv3552Rv35520.917
Rv0971cechA70.917
Rv0632cechA30.917
Rv0860fadB0.909
Rv0860fadB0.909
Rv0860fadB0.909
Rv3551Rv35510.907
Rv3774echA210.902
Rv1058fadD140.902
Rv1058fadD140.902
Rv2790cltp10.901
Rv2790cltp10.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.907785.55
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
adenosine monophosphatePubChem0.9347.221