Rv3505

Tuberculist information
Gene namefadE27
Protein functionProbable acyl-CoA dehydrogenase FadE27
Functional category(tuberculist)lipid metabolism
Gene location(kb)3923.7
Molecular mass(da)39007.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 373
	  		  	1    MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFDRELWRKLIDAGILSSAAPES   60
			  	61   LGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLAAGALARFGSPELQQGWGVSAVSGDRI  120
			  	121  LTVALDGEMGEGPVQAAGTGHGYRLTGTRTQVGYGPVADAFLVPAETDSGAAVFLVAAGD  180
			  	181  PGVAVTALATTGLGSVGHLELNGAKVDAARRVGGTDVAVWLGTLSTLSRTAFQLGVLERG  240
			  	241  LQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAAWRVAEDSLASRECP  300
			  	301  QPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKQTEFALGGATGQ  360
			  	361  LRRIGRELAETPA

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 6 to 118  |  Coverage: 30% Acyl-CoA_dh_N Range: 213 to 369  |  Coverage: 41% Acyl-CoA_dh_1 Range: 1 to 368  |  Coverage: 98% 1 Range: 1 to 373  |  Coverage: 99% 1 Range: 213 to 369  |  Coverage: 41% 2 Range: 6 to 118  |  Coverage: 30% 3 Range: 155 to 373  |  Coverage: 58% 4
Number of amino acids : 373
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027716-118
Acyl-CoA_dh_1PF00441213-369
Mtb Structural Proteome models
Model Number1
Model nameRv3505
Template1BUC    APDBCREDO
Template coverage1_381
Template Identity(%)27.7
Model coverage(%)98.4
Normalized DOPE score-0.569

Structure Models from Chopin
Model Number1
Profilea.29.3.1, e.6.1.1
Click for model details
zscore37.24
Residue begin1
Residue end373
Model Number2
Profilea.29.3.1
Click for model details
zscore26.59
Residue begin213
Residue end369
Model Number3
Profile1.10.540.10
Click for model details
zscore14
Residue begin6
Residue end118
Model Number4
Profile1.20.140.10
Click for model details
zscore9.9
Residue begin155
Residue end373
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3505Gene nameConfidence Score
Rv3516echA190.963
Rv3550echA200.96
Rv3506fadD170.939
Rv3506fadD170.939
Rv3504fadE260.939
Rv3504fadE260.939
Rv3504fadE260.939
Rv0632cechA30.935
Rv0456cechA20.934
Rv2679echA150.934
Rv1935cechA130.931
Rv0675echA50.931
Rv2831echA160.93
Rv1141cechA110.93
Rv0673echA40.93
Rv1071cechA90.928
Rv1071cechA90.928
Rv0971cechA70.92
Rv0222echA10.92
Rv1142cechA100.92
Rv3774echA210.909
Rv2790cltp10.901
Rv2790cltp10.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine monophosphatePubChem0.9347.221
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
flavin adenine dinucleotidePubChem0.9785.55
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073