Rv0222

Tuberculist information
Gene nameechA1
Protein functionProbable enoyl-CoA hydratase EchA1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)265.507
Molecular mass(da)27280.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 262
	  		  	1    MSSESDAANTEPEVLVEQRDRILIITINRPKAKNAVNAAVSRGLADAMDQLDGDAGLSVA   60
			  	61   ILTGGGGSFCAGMDLKAFARGENVVVEGRGLGFTERPPTKPLIAAVEGYALAGGTELALA  120
			  	121  ADLIVAARDSAFGIPEVKRGLVAGGGGLLRLPERIPYAIAMELALTGDNLPAERAHELGL  180
			  	181  VNVLAEPGTALDAAIALAEKITANGPLAVVATKRIITESRGWSPDTMFAEQMKILVPVFT  240
			  	241  SNDAKEGAIAFAERRRPRWTGT

Known structures in the PDB
PDB ID4JJT
Total residue count756
Number of chains3
MethodX-RAY
Resolution2.5
1 27 53 79 105 131 157 183 209 235 261 Range: 15 to 254  |  Coverage: 91% ECH Range: 14 to 260  |  Coverage: 93% 1 Range: 1 to 262  |  Coverage: 99% 1 Range: 203 to 262  |  Coverage: 22% 2
Number of amino acids : 262
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF0037815-254
Mtb Structural Proteome models
Model Number1
Model nameRv0222
Template1MJ3    APDBCREDO
Template coverage36_288
Template Identity(%)32.8
Model coverage(%)93.9
Normalized DOPE score-0.259

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore31.15
Residue begin1
Residue end262
Model Number2
Profile1.10.12.10
Click for model details
zscore12.93
Residue begin203
Residue end262
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0222Gene nameConfidence Score
Rv0468fadB20.966
Rv0468fadB20.966
Rv1715fadB30.935
Rv1715fadB30.935
Rv1467cfadE150.93
Rv1467cfadE150.93
Rv1467cfadE150.93
Rv1467cfadE150.93
Rv1467cfadE150.93
Rv3563fadE320.929
Rv3563fadE320.929
Rv3562fadE310.928
Rv1679fadE160.928
Rv3562fadE310.928
Rv1934cfadE170.928
Rv1679fadE160.928
Rv1934cfadE170.928
Rv0860fadB0.928
Rv1679fadE160.928
Rv1934cfadE170.928
Rv0860fadB0.928
Rv0860fadB0.928
Rv3562fadE310.928
Rv1933cfadE180.927
Rv1933cfadE180.927
Rv0154cfadE20.92
Rv0271cfadE60.92
Rv0131cfadE10.92
Rv3505fadE270.92
Rv0131cfadE10.92
Rv3505fadE270.92
Rv0131cfadE10.92
Rv0231fadE40.92
Rv3564fadE330.92
Rv0154cfadE20.92
Rv0271cfadE60.92
Rv0231fadE40.92
Rv3564fadE330.92
Rv0154cfadE20.92
Rv0271cfadE60.92
Rv3560cfadE300.919
Rv3560cfadE300.919
Rv3543cfadE290.919
Rv3560cfadE300.919
Rv3543cfadE290.919
Rv3543cfadE290.919
Rv3504fadE260.917
Rv3504fadE260.917
Rv2502caccD10.917
Rv3504fadE260.917
Rv3544cfadE280.915
Rv3544cfadE280.915
Rv0244cfadE50.914
Rv0244cfadE50.914
Rv0244cfadE50.914
Rv0244cfadE50.914
Rv0244cfadE50.914
Rv0215cfadE30.912
Rv0215cfadE30.912
Rv0215cfadE30.912
Rv3761cfadE360.912
Rv3274cfadE250.911
Rv3274cfadE250.911
Rv3274cfadE250.911
Rv2724cfadE200.909
Rv2724cfadE200.909
Rv2724cfadE200.909
Rv0752cfadE90.908
Rv0752cfadE90.908
Rv0752cfadE90.908
Rv0400cfadE70.906
Rv0400cfadE70.906
Rv0400cfadE70.906
Rv0975cfadE130.902
Rv0975cfadE130.902
Rv0975cfadE130.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.915835.608
3-hydroxybutyryl-CoAPubChem0.905853.623
methacrylyl-CoAPubChem0.903835.608
acryloyl-CoAPubChem0.903821.581
3-hydroxypropionyl-CoAPubChem0.902839.597
H(+)PubChem0.9012.01588
C05268PubChem0.9881.677
C04405PubChem0.9867.65
C0885PubChem0.9917.752
methylcrotonyl CoAPubChem0.9849.635
C16468PubChem0.9875.672
AR-1A9122PubChem0.9787.566
c0887PubChem0.9935.767
flavin adenine dinucleotidePubChem0.9785.55
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05271PubChem0.9863.661
deuteriumPubChem0.92.01588
C11945PubChem0.9917.752
C05262PubChem0.9965.836
2-methylbutyryl-CoAPubChem0.9851.651
C01144PubChem0.9853.623
C05273PubChem0.9975.874
NAD+PubChem0.9663.425
protiumPubChem0.92.01576
2-methylacetoacetyl-coenzyme APubChem0.9865.634
C05266PubChem0.9909.73
3-methylcrotonyl-CoAPubChem0.9849.635
C03221PubChem0.9947.821
hydroxyl radicalsPubChem0.917.0073
CHEBI:15477PubChem0.9851.651
NSC112207PubChem0.9785.55
3-hydroxypropionyl-coenzyme APubChem0.9839.597
C05258PubChem0.91021.94
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C16469PubChem0.9893.687
C05275PubChem0.9919.768
1,5-dihydro-FADPubChem0.9787.566
C11947PubChem0.9935.767
C05260PubChem0.9993.889
2-methylacetoacetyl-CoAPubChem0.9865.634
trans-2-hexadecenoyl-CoAPubChem0.91003.93
2MCPubChem0.9835.608
C14145PubChem0.9911.659
3-hydroxydecanoyl-CoAPubChem0.9937.783
3-hydroxyadipyl-CoAPubChem0.9911.659
FADH2PubChem0.9787.566
C05276PubChem0.9891.714
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C11946PubChem0.9917.752
alpha-methylbutyryl-CoAPubChem0.9851.651