Rv1934c

Tuberculist information
Gene namefadE17
Protein functionProbable acyl-CoA dehydrogenase FadE17
Functional category(tuberculist)lipid metabolism
Gene location(kb)2184.96
Molecular mass(da)44651.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 409
	  		  	1    VDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPPHEREEFARHWRRALAGAGLVAVSW   60
			  	61   PTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLLGIDLLGNTLIALGSEAQKRHFLPRI  120
			  	121  LSGEHRWCQGFSEPEAGSDLASVRTRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDP  180
			  	181  SAAKHRGLSFLLVPMDQPGVVVRPIVNAAGHSSFSEVFLTDARTSAGNVVGRVGDGWSTA  240
			  	241  MTLLGFERGSHIATAAIDFERDLQRLCELARDRGLHTDPRVRDGLAWCYARVQIMRYRGY  300
			  	301  RDLTLALTGRPPGAEAAITKVIWSEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAG  360
			  	361  TPNSPACWMDELLYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 6 to 124  |  Coverage: 28% Acyl-CoA_dh_N Range: 128 to 179  |  Coverage: 12% Acyl-CoA_dh_M Range: 234 to 397  |  Coverage: 39% Acyl-CoA_dh_1 Range: 2 to 398  |  Coverage: 96% 1 Range: 1 to 405  |  Coverage: 98% 1 Range: 234 to 397  |  Coverage: 39% 2 Range: 115 to 246  |  Coverage: 32% 3 Range: 6 to 124  |  Coverage: 28% 4 Range: 128 to 179  |  Coverage: 12% 5 Range: 1 to 404  |  Coverage: 98% 6
Number of amino acids : 409
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027716-124
Acyl-CoA_dh_MPF02770128-179
Acyl-CoA_dh_1PF00441234-397
Mtb Structural Proteome models
Model Number1
Model nameRv1934c
Template1JQI    APDBCREDO
Template coverage7_384
Template Identity(%)27.0
Model coverage(%)96.8
Normalized DOPE score-0.584

Structure Models from Chopin
Model Number1
Profile1.20.140.10, 2.40.110.10
Click for model details
zscore33.86
Residue begin1
Residue end405
Model Number2
Profilea.29.3.1
Click for model details
zscore16.14
Residue begin234
Residue end397
Model Number3
Profile2.40.110.10
Click for model details
zscore14.87
Residue begin115
Residue end246
Model Number4
Profile1.10.540.10
Click for model details
zscore13.91
Residue begin6
Residue end124
Model Number5
Profilee.6.1.1
Click for model details
zscore12.24
Residue begin128
Residue end179
Model Number6
Profilee.6.1.1
Click for model details
zscore9.92
Residue begin1
Residue end404
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1934cGene nameConfidence Score
Rv1935cechA130.987
Rv0675echA50.943
Rv0456cechA20.942
Rv2679echA150.94
Rv1933cfadE180.935
Rv1933cfadE180.935
Rv1141cechA110.934
Rv0673echA40.934
Rv3550echA200.934
Rv2831echA160.933
Rv1071cechA90.931
Rv1071cechA90.931
Rv1142cechA100.93
Rv0971cechA70.93
Rv0222echA10.928
Rv0632cechA30.928
Rv3552Rv35520.921
Rv3551Rv35510.92
Rv3516echA190.918
Rv1058fadD140.914
Rv1058fadD140.914
Rv3774echA210.913
Rv0860fadB0.909
Rv0860fadB0.909
Rv0860fadB0.909
Rv2790cltp10.905
Rv2790cltp10.905
Rv3561fadD30.902
Rv3561fadD30.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.903785.55
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
adenosine monophosphatePubChem0.9347.221