Rv1933c

Tuberculist information
Gene namefadE18
Protein functionProbable acyl-CoA dehydrogenase FadE18
Functional category(tuberculist)lipid metabolism
Gene location(kb)2183.87
Molecular mass(da)38477.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 363
	  		  	1    VDFRYSTEQDDFRASLRGFLGRGAPVREMAAADGSDRRLWQRLCTELELPALHVPPEHGG   60
			  	61   LGATLVETAIAFAELGRALTPIPFAATVFAIEAILRMGDDEQRKRLLAGLLTGARIGTIA  120
			  	121  VSGHDVASATTVRAVRRDGRPALTGECTPVLHGHVADLFVVPAVADGSIVLHVVAADAPG  180
			  	181  VTVTPLPSFDITRPVATLRLAGSPAEPLTAGTPDDMERVLDVARVLLAAEMLGGAEACLD  240
			  	241  LAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSAANGDELQTVAPLA  300
			  	301  KAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGL  360
			  	361  VKA

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 6 to 114  |  Coverage: 29% Acyl-CoA_dh_N Range: 210 to 359  |  Coverage: 41% Acyl-CoA_dh_1 Range: 1 to 363  |  Coverage: 99% 1 Range: 1 to 363  |  Coverage: 99% 1 Range: 210 to 359  |  Coverage: 41% 2 Range: 6 to 114  |  Coverage: 29% 3
Number of amino acids : 363
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027716-114
Acyl-CoA_dh_1PF00441210-359
Mtb Structural Proteome models
Model Number1
Model nameRv1933c
Template2D29    APDBCREDO
Template coverage3_386
Template Identity(%)25.3
Model coverage(%)99.5
Normalized DOPE score-0.425

Structure Models from Chopin
Model Number1
Profilea.29.3.1, e.6.1.1
Click for model details
zscore35.46
Residue begin1
Residue end363
Model Number2
Profilea.29.3.1
Click for model details
zscore32.7
Residue begin210
Residue end359
Model Number3
Profile1.10.540.10
Click for model details
zscore11.66
Residue begin6
Residue end114
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1933cGene nameConfidence Score
Rv1935cechA130.995
Rv0456cechA20.946
Rv2679echA150.94
Rv0675echA50.937
Rv1934cfadE170.935
Rv1934cfadE170.935
Rv1934cfadE170.935
Rv3550echA200.934
Rv0673echA40.933
Rv2831echA160.931
Rv1071cechA90.931
Rv1071cechA90.931
Rv1141cechA110.931
Rv1142cechA100.93
Rv0971cechA70.928
Rv0632cechA30.928
Rv0222echA10.927
Rv1941Rv19410.925
Rv3552Rv35520.924
Rv3551Rv35510.922
Rv3516echA190.917
Rv3774echA210.911
Rv0860fadB0.907
Rv0860fadB0.907
Rv0860fadB0.907
Rv3561fadD30.906
Rv3561fadD30.906
Rv2790cltp10.902
Rv2790cltp10.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
flavin adenine dinucleotidePubChem0.9785.55
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
coenzyme APubChem0.9767.534
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
adenosine monophosphatePubChem0.9347.221