Rv1941

Tuberculist information
Gene nameRv1941
Protein functionProbable short-chain type dehydrogenase/reductase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2193.66
Molecular mass(da)25816.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 256
	  		  	1    LNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADIDGDAADAAATKIGCGAAACR   60
			  	61   VDVSDEQQIIAMVDACVAAFGGVDKLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLC  120
			  	121  TKHAAPRMIERGGGAIVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSSGIRSN  180
			  	181  TLLPAFVDTPMQQTAMAMFDGALGAGGARSMIARLQGRMAAPEEMAGIVVFLLSDDASMI  240
			  	241  TGTTQIADGGTIAALW

Known structures in the PDB
PDB ID3GVC
Total residue count1108
Number of chains4
MethodX-RAY
Resolution2.45
1 26 51 76 101 126 151 176 201 226 251 Range: 9 to 173  |  Coverage: 64% adh_short Range: 27 to 277  |  Coverage: 97% 1 Range: 5 to 254  |  Coverage: 97% 2 Range: 1 to 256  |  Coverage: 99% 1
Number of amino acids : 256
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
adh_shortPF001069-173
Mtb Structural Proteome models
Model Number1
Model nameRv1941_3gvc_A
Template3GVC    APDBCREDO
Template coverage27_277
Template Identity(%)100.0
Model coverage(%)97.3
Normalized DOPE score-0.684

Model Number2
Model nameRv1941
Template1HDC    APDBCREDO
Template coverage3_246
Template Identity(%)37.0
Model coverage(%)96.9
Normalized DOPE score0.274

Structure Models from Chopin
Model Number1
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore17.86
Residue begin1
Residue end256
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1941Gene nameConfidence Score
Rv1936Rv19360.981
Rv1937Rv19370.979
Rv1937Rv19370.979
Rv1937Rv19370.979
Rv1933cfadE180.925
Rv1933cfadE180.925
Rv1935cechA130.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions