Rv3550

Tuberculist information
Gene nameechA20
Protein functionProbable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3989.15
Molecular mass(da)26332.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 247
	  		  	1    MPITSTTPEPGIVAVTVDYPPVNAIPSKAWFDLADAVTAAGANSDTRAVILRAEGRGFNA   60
			  	61   GVDIKEMQRTEGFTALIDANRGCFAAFRAVYECAVPVIAAVNGFCVGGGIGLVGNSDVIV  120
			  	121  ASEDATFGLPEVERGALGAATHLSRLVPQHLMRRLFFTAATVDAATLQHFGSVHEVVSRD  180
			  	181  QLDEAALRVARDIAAKDTRVIRAAKEALNFIDVQRVNASYRMEQGFTFELNLAGVADEHR  240
			  	241  DAFVKKS

Known structures in the PDB
No Known structures
1 25 49 73 97 121 145 169 193 217 241 Range: 5 to 238  |  Coverage: 94% ECH Range: 3 to 246  |  Coverage: 98% 1 Range: 1 to 247  |  Coverage: 99% 1 Range: 195 to 247  |  Coverage: 21% 2
Number of amino acids : 247
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF003785-238
Mtb Structural Proteome models
Model Number1
Model nameRv3550
Template1MJ3    APDBCREDO
Template coverage36_282
Template Identity(%)26.6
Model coverage(%)98.4
Normalized DOPE score-0.587

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore33.13
Residue begin1
Residue end247
Model Number2
Profile1.10.12.10
Click for model details
zscore10.05
Residue begin195
Residue end247
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3550Gene nameConfidence Score
Rv3551Rv35510.996
Rv3552Rv35520.996
Rv3560cfadE300.985
Rv3560cfadE300.985
Rv3560cfadE300.985
Rv3562fadE310.982
Rv3562fadE310.982
Rv3562fadE310.982
Rv3563fadE320.965
Rv3563fadE320.965
Rv3505fadE270.96
Rv3505fadE270.96
Rv3504fadE260.959
Rv3504fadE260.959
Rv3504fadE260.959
Rv3544cfadE280.95
Rv3544cfadE280.95
Rv1715fadB30.946
Rv1715fadB30.946
Rv1550fadD110.945
Rv0271cfadE60.939
Rv0271cfadE60.939
Rv0271cfadE60.939
Rv3543cfadE290.937
Rv3543cfadE290.937
Rv0468fadB20.937
Rv0468fadB20.937
Rv3543cfadE290.937
Rv3564fadE330.936
Rv3564fadE330.936
Rv1933cfadE180.934
Rv1933cfadE180.934
Rv1934cfadE170.934
Rv1934cfadE170.934
Rv1934cfadE170.934
Rv1679fadE160.931
Rv1679fadE160.931
Rv1679fadE160.931
Rv1467cfadE150.93
Rv1467cfadE150.93
Rv0231fadE40.93
Rv0131cfadE10.93
Rv0231fadE40.93
Rv0131cfadE10.93
Rv1467cfadE150.93
Rv0131cfadE10.93
Rv1467cfadE150.93
Rv1467cfadE150.93
Rv0154cfadE20.923
Rv0154cfadE20.923
Rv0154cfadE20.923
Rv0860fadB0.92
Rv0860fadB0.92
Rv0860fadB0.92
Rv2502caccD10.903
Rv0244cfadE50.902
Rv0244cfadE50.902
Rv0244cfadE50.902
Rv0244cfadE50.902
Rv0244cfadE50.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.901835.608
C0885PubChem0.9917.752
methylcrotonyl CoAPubChem0.9849.635
methacrylyl-CoAPubChem0.9835.608
c0887PubChem0.9935.767
C16469PubChem0.9893.687
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
C05258PubChem0.91021.94
C05271PubChem0.9863.661
3-hydroxyadipyl-CoAPubChem0.9911.659
C05262PubChem0.9965.836
C11947PubChem0.9935.767
C05273PubChem0.9975.874
3-hydroxybutyryl-CoAPubChem0.9853.623
C05266PubChem0.9909.73
C14145PubChem0.9911.659
C03221PubChem0.9947.821
2MCPubChem0.9835.608
C01144PubChem0.9853.623
3-hydroxypropionyl-coenzyme APubChem0.9839.597
C16468PubChem0.9875.672
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C04405PubChem0.9867.65
C05275PubChem0.9919.768
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
C05260PubChem0.9993.889
3-hydroxypropionyl-CoAPubChem0.9839.597
trans-2-hexadecenoyl-CoAPubChem0.91003.93
3-methylcrotonyl-CoAPubChem0.9849.635
3-hydroxydecanoyl-CoAPubChem0.9937.783
C11945PubChem0.9917.752
C05276PubChem0.9891.714
acryloyl-CoAPubChem0.9821.581
C05268PubChem0.9881.677
C11946PubChem0.9917.752