Rv1550

Tuberculist information
Gene namefadD11
Protein functionProbable fatty-acid-CoA ligase FadD11 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1753.72
Molecular mass(da)62309.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 571
	  		  	1    MARLRGAGAAGRCRPGRFGSSARRHGLADDGEPDRVLPARRRCSARRRHLVFGVQHPARR   60
			  	61   AADLRVRQRGDQGGHLRATVRRSRSRQRCAHRTHRLRRWRAPGTLSLTDLYAAASGDFFD  120
			  	121  FESTWRAVQPEDIVTLIYTSGTTGNPKGVEMTHANLLFEGYAIDEVLGIRFGDRVTSFLP  180
			  	181  SAHIADRMTGLYLQEMFGTQVTAVADARTIAAALPDVRPTVWGAVPRVWEKLKAGIEFTV  240
			  	241  ARETDEMKRQALAWAMSVAGKRANALLAGESMSDQLVAEWAKADELVLSKLRERLGFGEL  300
			  	301  RWALSGAAPIPKETLAFFAGIGIPIAEIWGMSELSCVATASHPRDGRLGTVGKLLPGLQG  360
			  	361  KIAEDGEYLVRGPLVMKGYRKEPAKTAEAIDSDGWLHTGDVFDIDSDGYLRVVDRKKELI  420
			  	421  INAAGKNMSPANIENTILAACPMVGVMMAIGDGRTYNTALLVFDADSLGPYAAQRGLDAS  480
			  	481  PAALAADPEVIARIAAGVAEGNAKLSRVEQIKRFRILPTLWEPGGDEITLTMKLKRRRIA  540
			  	541  AKYSAEIEELYASELRPQVYEPAAVPSTQPA

Known structures in the PDB
No Known structures
1 58 115 172 229 286 343 400 457 514 571 Range: 80 to 448  |  Coverage: 64% AMP-binding Range: 1 to 571  |  Coverage: 99% 1 Range: 1 to 562  |  Coverage: 98% 1 Range: 352 to 415  |  Coverage: 11% 2
Number of amino acids : 571
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AMP-bindingPF0050180-448
Mtb Structural Proteome models
Model Number1
Model nameRv1550
Template1PG4    APDBCREDO
Template coverage96_647
Template Identity(%)15.7
Model coverage(%)99.8
Normalized DOPE score1.254

Structure Models from Chopin
Model Number1
Profilee.23.1.1
Click for model details
zscore21.32
Residue begin1
Residue end562
Model Number2
Profile2.30.38.10
Click for model details
zscore18.97
Residue begin352
Residue end415
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1550Gene nameConfidence Score
Rv1549fadD11.10.996
Rv3039cechA170.981
Rv1472echA120.97
Rv0860fadB0.956
Rv0860fadB0.956
Rv0860fadB0.956
Rv0673echA40.95
Rv2831echA160.949
Rv1071cechA90.949
Rv1071cechA90.949
Rv3550echA200.945
Rv1142cechA100.943
Rv0632cechA30.94
Rv1551plsB10.94
Rv0971cechA70.94
Rv0905echA60.934
Rv3774echA210.92
Rv0873fadE100.913
Rv0873fadE100.913
Rv0873fadE100.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
coenzyme APubChem0.928767.534
pyrophosphatePubChem0.901177.975
adenosine triphosphatePubChem0.9507.181
(3R)-3-isopropenyl-6-oxoheptanoatePubChem0.9183.224
FADH2PubChem0.9787.566
C0885PubChem0.9917.752
c0682PubChem0.9168.233
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
AR-1A9122PubChem0.9787.566
adenosine monophosphatePubChem0.9347.221
3-hydroxypropionyl-coenzyme APubChem0.9839.597
Co-APubChem0.9767.534
formatePubChem0.945.0174
trans-2-methyl-5-isopropylhexa-2,5-dienoic acidPubChem0.9168.233
3-hydroxypropionyl-CoAPubChem0.9839.597
flavin adenine dinucleotidePubChem0.9785.55
C11945PubChem0.9917.752
deuteriumPubChem0.92.01588
NSC112207PubChem0.9785.55
C11946PubChem0.9917.752
perillic acidPubChem0.9166.217
H(+)PubChem0.92.01588