Rv1549

Tuberculist information
Gene namefadD11.1
Protein functionPossible fatty-acid-CoA ligase FadD11.1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1753.51
Molecular mass(da)19303
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 175
	  		  	1    VVAAPCFRVLRLWTYAHRCDLGHTDPLSRRTEMTTTERPTTMCEAFQRTAVMDPDAVALR   60
			  	61   TPGGNQTMTWRDYAAQVRRVAAGLAGLGVRRGDTVSLMMANRIEFYPLDVGAQHVGATSF  120
			  	121  SVYNTLPAEQLTYVFDNAGTKVVICEQQYVDRVRASGVPIEHIVCVDGAPPARSR

Known structures in the PDB
No Known structures
1 18 35 52 69 86 103 120 137 154 171 Range: 46 to 174  |  Coverage: 73% AMP-binding Range: 40 to 170  |  Coverage: 74% 1 Range: 1 to 175  |  Coverage: 99% 1
Number of amino acids : 175
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AMP-bindingPF0050146-174
Mtb Structural Proteome models
Model Number1
Model nameRv1549
Template1T5H    XPDBCREDO
Template coverage2_138
Template Identity(%)24.4
Model coverage(%)73.9
Normalized DOPE score-1.01

Structure Models from Chopin
Model Number1
Profilee.23.1.1
Click for model details
zscore20.1
Residue begin1
Residue end175
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1549Gene nameConfidence Score
Rv1550fadD110.996
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C0885PubChem0.9917.752
c0682PubChem0.9168.233
C11946PubChem0.9917.752
3-hydroxypropionyl-coenzyme APubChem0.9839.597
trans-2-methyl-5-isopropylhexa-2,5-dienoic acidPubChem0.9168.233
3-hydroxypropionyl-CoAPubChem0.9839.597
C11945PubChem0.9917.752
perillic acidPubChem0.9166.217
(3R)-3-isopropenyl-6-oxoheptanoatePubChem0.9183.224