Rv1142c

Tuberculist information
Gene nameechA10
Protein functionProbable enoyl-CoA hydratase EchA10 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1269.15
Molecular mass(da)27648.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 268
	  		  	1    MSNYRIDTRTIVPGLAVTLADGVLSVTIDRPESLNSLTKPVLAGMADAIEGAATDPRVKV   60
			  	61   VRLGGAGRGFSSGGAISVDDVWASGPPTDTVAEANRTVRAIVALPQPVVAVVQGPTVGCG  120
			  	121  VSLALACDLVLASDNAFFMLAHTNVGLMPDGGASALVQAAIGRIRAMHMALLPDRVPAAE  180
			  	181  ALSWGLVSAVYPAADFDAEVDKLISRLLAGPALAIAKTKNAINAATLTELAPTLLRELDG  240
			  	241  QALLLRTDDFAEGATAFQQRRTPMFTGR

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 16 to 260  |  Coverage: 91% ECH Range: 12 to 265  |  Coverage: 94% 1 Range: 1 to 268  |  Coverage: 99% 1 Range: 209 to 268  |  Coverage: 22% 2
Number of amino acids : 268
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF0037816-260
Mtb Structural Proteome models
Model Number1
Model nameRv1142c
Template1WZ8    APDBCREDO
Template coverage9_263
Template Identity(%)28.0
Model coverage(%)94.4
Normalized DOPE score-0.325

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore35.07
Residue begin1
Residue end268
Model Number2
Profile1.10.12.10
Click for model details
zscore18.45
Residue begin209
Residue end268
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1142cGene nameConfidence Score
Rv1715fadB30.971
Rv1715fadB30.971
Rv0468fadB20.963
Rv0468fadB20.963
Rv1550fadD110.943
Rv0860fadB0.942
Rv0860fadB0.942
Rv0860fadB0.942
Rv1679fadE160.93
Rv1934cfadE170.93
Rv1679fadE160.93
Rv1934cfadE170.93
Rv3562fadE310.93
Rv1933cfadE180.93
Rv3562fadE310.93
Rv1933cfadE180.93
Rv1679fadE160.93
Rv3562fadE310.93
Rv1934cfadE170.93
Rv0231fadE40.928
Rv0131cfadE10.928
Rv0231fadE40.928
Rv0131cfadE10.928
Rv3564fadE330.928
Rv0131cfadE10.928
Rv3564fadE330.928
Rv1467cfadE150.926
Rv1467cfadE150.926
Rv1467cfadE150.926
Rv1467cfadE150.926
Rv1467cfadE150.926
Rv0154cfadE20.921
Rv0154cfadE20.921
Rv0154cfadE20.921
Rv3505fadE270.92
Rv3563fadE320.92
Rv3560cfadE300.92
Rv3505fadE270.92
Rv3563fadE320.92
Rv0271cfadE60.92
Rv3560cfadE300.92
Rv3543cfadE290.92
Rv0271cfadE60.92
Rv3560cfadE300.92
Rv3543cfadE290.92
Rv0271cfadE60.92
Rv3543cfadE290.92
Rv3504fadE260.919
Rv3504fadE260.919
Rv3504fadE260.919
Rv3544cfadE280.917
Rv3544cfadE280.917
Rv2502caccD10.916
Rv3761cfadE360.914
Rv0400cfadE70.908
Rv0400cfadE70.908
Rv0400cfadE70.908
Rv0244cfadE50.907
Rv0244cfadE50.907
Rv0244cfadE50.907
Rv0244cfadE50.907
Rv0244cfadE50.907
Rv3274cfadE250.903
Rv3274cfadE250.903
Rv3274cfadE250.903
Rv2724cfadE200.902
Rv2724cfadE200.902
Rv2724cfadE200.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.909835.608
C05268PubChem0.9881.677
3-hydroxybutyryl-CoAPubChem0.9853.623
C04405PubChem0.9867.65
C0885PubChem0.9917.752
methylcrotonyl CoAPubChem0.9849.635
C16468PubChem0.9875.672
AR-1A9122PubChem0.9787.566
c0887PubChem0.9935.767
flavin adenine dinucleotidePubChem0.9785.55
3-hydroxypropionyl-CoAPubChem0.9839.597
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05271PubChem0.9863.661
deuteriumPubChem0.92.01588
C11945PubChem0.9917.752
C05262PubChem0.9965.836
2-methylbutyryl-CoAPubChem0.9851.651
C01144PubChem0.9853.623
C05273PubChem0.9975.874
NAD+PubChem0.9663.425
protiumPubChem0.92.01576
2-methylacetoacetyl-coenzyme APubChem0.9865.634
C05266PubChem0.9909.73
3-methylcrotonyl-CoAPubChem0.9849.635
methacrylyl-CoAPubChem0.9835.608
C03221PubChem0.9947.821
hydroxyl radicalsPubChem0.917.0073
CHEBI:15477PubChem0.9851.651
NSC112207PubChem0.9785.55
3-hydroxypropionyl-coenzyme APubChem0.9839.597
C05258PubChem0.91021.94
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C16469PubChem0.9893.687
H(+)PubChem0.92.01588
C05275PubChem0.9919.768
1,5-dihydro-FADPubChem0.9787.566
C11947PubChem0.9935.767
C05260PubChem0.9993.889
2-methylacetoacetyl-CoAPubChem0.9865.634
acryloyl-CoAPubChem0.9821.581
trans-2-hexadecenoyl-CoAPubChem0.91003.93
2MCPubChem0.9835.608
C14145PubChem0.9911.659
3-hydroxydecanoyl-CoAPubChem0.9937.783
3-hydroxyadipyl-CoAPubChem0.9911.659
FADH2PubChem0.9787.566
C05276PubChem0.9891.714
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C11946PubChem0.9917.752
alpha-methylbutyryl-CoAPubChem0.9851.651