Rv0400c

Tuberculist information
Gene namefadE7
Protein functionAcyl-CoA dehydrogenase FadE7
Functional category(tuberculist)lipid metabolism
Gene location(kb)478.566
Molecular mass(da)42297.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 395
	  		  	1    MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAAWFEDGDLPVARDLA   60
			  	61   KQFGELGLLGMQLHGHGCGGASAVHYGLACRELEAADSGIRSLVSVQGSLAMFAIASFGS  120
			  	121  DEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARRDGPDWVITGGKMWITNGSVA  180
			  	181  DVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAMLPGA  240
			  	241  TGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRPIAGFQLTQAKLVDMA  300
			  	301  VELHKGQLLSLHLGRLKDRVGLRPDQVSFGKLNNTREALKICRTARTILGGNGISLEYPV  360
			  	361  IRHMVNLESVLTYEGTPEMHQLVLGQAFTGLAAFR

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 22 to 135  |  Coverage: 28% Acyl-CoA_dh_N Range: 139 to 191  |  Coverage: 13% Acyl-CoA_dh_M Range: 240 to 389  |  Coverage: 37% Acyl-CoA_dh_1 Range: 9 to 395  |  Coverage: 97% 1 Range: 8 to 395  |  Coverage: 97% 1 Range: 238 to 395  |  Coverage: 39% 2 Range: 9 to 378  |  Coverage: 93% 3 Range: 22 to 135  |  Coverage: 28% 4 Range: 136 to 252  |  Coverage: 29% 5
Number of amino acids : 395
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF0277122-135
Acyl-CoA_dh_MPF02770139-191
Acyl-CoA_dh_1PF00441240-389
Mtb Structural Proteome models
Model Number1
Model nameRv0400c
Template1SIQ    APDBCREDO
Template coverage4_391
Template Identity(%)48.6
Model coverage(%)97.7
Normalized DOPE score-0.954

Structure Models from Chopin
Model Number1
Profilea.29.3.1, e.6.1.1 - 1.10.540.10, 1.20.140.10, 2.40.110.10
Click for model details
zscore69.81
Residue begin8
Residue end395
Model Number2
Profilea.29.3.1
Click for model details
zscore34.51
Residue begin238
Residue end395
Model Number3
Profilee.6.1.1
Click for model details
zscore22.97
Residue begin9
Residue end378
Model Number4
Profile1.10.540.10
Click for model details
zscore20.34
Residue begin22
Residue end135
Model Number5
Profile2.40.110.10
Click for model details
zscore16.57
Residue begin136
Residue end252
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0400cGene nameConfidence Score
Rv0860fadB0.934
Rv0860fadB0.934
Rv0860fadB0.934
Rv1070cechA80.927
Rv1071cechA90.922
Rv1071cechA90.922
Rv2679echA150.913
Rv1142cechA100.908
Rv0975cfadE130.907
Rv0975cfadE130.907
Rv0975cfadE130.907
Rv1141cechA110.906
Rv3516echA190.906
Rv0222echA10.906
Rv0905echA60.905
Rv3774echA210.905
Rv1472echA120.905
Rv2831echA160.904
Rv0154cfadE20.904
Rv0154cfadE20.904
Rv0154cfadE20.904
Rv3039cechA170.903
Rv0675echA50.903
Rv2486echA140.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.97785.55
glutaryl-CoAPubChem0.935881.633
glutaryl coenzyme APubChem0.934881.633
crotonyl-CoAPubChem0.934835.608
coenzyme APubChem0.915767.534
formatePubChem0.90645.0174
pyrophosphatePubChem0.9177.975
Co-APubChem0.9767.534
FADH2PubChem0.9787.566
crotonyl-coenzyme APubChem0.9835.608
NSC112207PubChem0.9785.55
adenosine triphosphatePubChem0.9507.181
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
protiumPubChem0.92.01576
1,5-dihydro-FADPubChem0.9787.566
adenosine monophosphatePubChem0.9347.221
deuteriumPubChem0.92.01588
AR-1A9122PubChem0.9787.566
carbon dioxidePubChem0.944.0095