Rv0975c

Tuberculist information
Gene namefadE13
Protein functionProbable acyl-CoA dehydrogenase FadE13
Functional category(tuberculist)lipid metabolism
Gene location(kb)1087.35
Molecular mass(da)40715.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 382
	  		  	1    VNIWTTPERQQLRKTVRAFAEREILPHVDEWERIGELPRGLHRLAGAAGLLGAGFPEAVG   60
			  	61   GGGGDGADPVIICEEMHQAGAPGGVYASLFTCGIAVPHMVASGDERLIATYVRPTLAGEK  120
			  	121  IGALAITEPGGGSDVGHLRTSAVRDGDHYVINGAKTYITSGVRADYVVTAVRTGGPGAAG  180
			  	181  VSLLVVEKDTPGFEVTRKLDKMGWRSSDTAELCYTDVAVPATNLVGAENSGFTQIARAFV  240
			  	241  SERIGLAAQAYSSAQRCLDLTAQWCRDRETFGRPLISRQSVQNTLAEMARRIDVARVYAH  300
			  	301  HVVERQLAGETDLIAQVCFAKNTAVQAGEWVANQAVQLFGGMGYMAESEVERQYRDMRIL  360
			  	361  GIGGGTTEILTALAAKTLGYQS

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 6 to 119  |  Coverage: 29% Acyl-CoA_dh_N Range: 123 to 175  |  Coverage: 13% Acyl-CoA_dh_M Range: 229 to 379  |  Coverage: 39% Acyl-CoA_dh_1 Range: 1 to 378  |  Coverage: 98% 1 Range: 1 to 382  |  Coverage: 99% 1 Range: 227 to 382  |  Coverage: 40% 2 Range: 6 to 119  |  Coverage: 29% 3 Range: 1 to 232  |  Coverage: 60% 4 Range: 1 to 370  |  Coverage: 96% 5
Number of amino acids : 382
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027716-119
Acyl-CoA_dh_MPF02770123-175
Acyl-CoA_dh_1PF00441229-379
Mtb Structural Proteome models
Model Number1
Model nameRv0975c
Template1UKW    APDBCREDO
Template coverage32_407
Template Identity(%)35.1
Model coverage(%)98.7
Normalized DOPE score-0.806

Structure Models from Chopin
Model Number1
Profile1.20.140.10, 2.40.110.10
Click for model details
zscore71.62
Residue begin1
Residue end382
Model Number2
Profilea.29.3.1
Click for model details
zscore36.88
Residue begin227
Residue end382
Model Number3
Profile1.10.540.10
Click for model details
zscore21.62
Residue begin6
Residue end119
Model Number4
Profilee.6.1.1
Click for model details
zscore20.71
Residue begin1
Residue end232
Model Number5
Profilee.6.1.2
Click for model details
zscore9.13
Residue begin1
Residue end370
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0975cGene nameConfidence Score
Rv0971cechA70.992
Rv0973caccA20.985
Rv0973caccA20.985
Rv0973caccA20.985
Rv0973caccA20.985
Rv3774echA210.973
Rv0859fadA0.95
Rv0859fadA0.95
Rv0976cRv0976c0.95
Rv1074cfadA30.948
Rv1074cfadA30.948
Rv3556cfadA60.946
Rv3556cfadA60.946
Rv3546fadA50.94
Rv3546fadA50.94
Rv1323fadA40.937
Rv1323fadA40.937
Rv0914cRv0914c0.935
Rv0914cRv0914c0.935
Rv0243fadA20.933
Rv0243fadA20.933
Rv2790cltp10.928
Rv2790cltp10.928
Rv0860fadB0.927
Rv0860fadB0.927
Rv0860fadB0.927
Rv3667acs0.924
Rv1071cechA90.924
Rv3667acs0.924
Rv1071cechA90.924
Rv2502caccD10.924
Rv0632cechA30.916
Rv1070cechA80.915
Rv0408pta0.914
Rv0408pta0.914
Rv0408pta0.914
Rv3561fadD30.91
Rv1867Rv18670.91
Rv3561fadD30.91
Rv0400cfadE70.907
Rv0166fadD50.907
Rv0400cfadE70.907
Rv0166fadD50.907
Rv0400cfadE70.907
Rv0753cmmsA0.906
Rv0972cfadE120.906
Rv0972cfadE120.906
Rv0972cfadE120.906
Rv1058fadD140.905
Rv1058fadD140.905
Rv3280accD50.905
Rv3523ltp30.902
Rv0222echA10.902
Rv2187fadD150.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.942785.55
octanoyl-CoAPubChem0.918893.73
butyryl-CoAPubChem0.914837.624
propionyl-CoAPubChem0.912823.597
1,5-dihydro-FADPubChem0.911787.566
hexanoyl-CoAPubChem0.908865.677
coenzyme APubChem0.908767.534
methacrylyl-CoAPubChem0.907835.608
acryloyl-CoAPubChem0.905821.581
palmitoyl-CoAPubChem0.9041005.94
trans-2-enoyl-CoAsPubChem0.904821.581
crotonyl-CoAPubChem0.904835.608
2MCPubChem0.903835.608
formatePubChem0.90345.0174
3-methylcrotonyl-CoAPubChem0.902849.635
lauroyl-CoAPubChem0.902949.837
myristoyl-CoAPubChem0.901977.89
C05273PubChem0.9975.874
AR-1A9122PubChem0.9787.566
adenosine triphosphatePubChem0.9507.181
C03221PubChem0.9947.821
Co-APubChem0.9767.534
FADH2PubChem0.9787.566
C05275PubChem0.9919.768
protiumPubChem0.92.01576
trans-2-hexadecenoyl-CoAPubChem0.91003.93
NSC112207PubChem0.9785.55
methylcrotonyl CoAPubChem0.9849.635
adenosine monophosphatePubChem0.9347.221
C05276PubChem0.9891.714
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
decanoyl-CoAPubChem0.9921.783
hydroxyl radicalsPubChem0.917.0073
pyrophosphatePubChem0.9177.975
C05271PubChem0.9863.661