Rv2187

Tuberculist information
Gene namefadD15
Protein functionLong-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2448.16
Molecular mass(da)64002.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 600
	  		  	1    VREISVPAPFTVGEHDNVAAMVFEHERDDPDYVIYQRLIDGVWTDVTCAEAANQIRAAAL   60
			  	61   GLISLGVQAGDRVVIFSATRYEWAILDFAILAVGAVTVPTYETSSAEQVRWVLQDSEAVV  120
			  	121  LFAETDSHATMVAELSGSVPALREVLQIAGSGPNALDRLTEAGASVDPAELTARLAALRS  180
			  	181  TDPATLIYTSGTTGRPKGCQLTQSNLVHEIKGARAYHPTLLRKGERLLVFLPLAHVLARA  240
			  	241  ISMAAFHSKVTVGFTSDIKNLLPMLAVFKPTVVVSVPRVFEKVYNTAEQNAANAGKGRIF  300
			  	301  AIAAQTAVDWSEACDRGGPGLLLRAKHAVFDRLVYRKLRAALGGNCRAAVSGGAPLGARL  360
			  	361  GHFYRGAGLTIYEGYGLSGTSGGVAISQFNDLKIGTVGKPVPGNSLRIADDGELLVRGGV  420
			  	421  VFSGYWRNEQATTEAFTDGWFKTGDLGAVDEDGFLTITGRKKEIIVTAGGKNVAPAVLED  480
			  	481  QLRAHPLISQAVVVGDAKPFIGALITIDPEAFEGWKQRNSKTAGASVGDLATDPDLIAEI  540
			  	541  DAAVKQANLAVSHAESIRKFRILPVDFTEDTGELTPTMKVKRKVVAEKFASDIEAIYNKE  600

Known structures in the PDB
No Known structures
1 61 121 181 241 301 361 421 481 541 601 Range: 22 to 468  |  Coverage: 74% AMP-binding Range: 7 to 591  |  Coverage: 97% 1 Range: 1 to 600  |  Coverage: 99% 1 Range: 387 to 460  |  Coverage: 12% 2
Number of amino acids : 600
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AMP-bindingPF0050122-468
Mtb Structural Proteome models
Model Number1
Model nameRv2187
Template2D1S    APDBCREDO
Template coverage14_543
Template Identity(%)24.2
Model coverage(%)97.3
Normalized DOPE score0.533

Structure Models from Chopin
Model Number1
Profilee.23.1.1
Click for model details
zscore35.36
Residue begin1
Residue end600
Model Number2
Profile2.30.38.10
Click for model details
zscore17.47
Residue begin387
Residue end460
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2187Gene nameConfidence Score
Rv0154cfadE20.905
Rv0154cfadE20.905
Rv0154cfadE20.905
Rv0975cfadE130.901
Rv0975cfadE130.901
Rv0975cfadE130.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
coenzyme APubChem0.938767.534
palmitoyl-CoAPubChem0.9191005.94
palmitatePubChem0.917256.424
Co-APubChem0.905767.534
octanoatePubChem0.905144.211
pyrophosphatePubChem0.901177.975
octanoyl-CoAPubChem0.901893.73
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
octanalPubChem0.9128.212
CO8PubChem0.9893.73
NAD+PubChem0.9663.425
adenosine monophosphatePubChem0.9347.221
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
adenosine triphosphatePubChem0.9507.181