Rv0972c

Tuberculist information
Gene namefadE12
Protein functionAcyl-CoA dehydrogenase FadE12
Functional category(tuberculist)lipid metabolism
Gene location(kb)1082.58
Molecular mass(da)41483.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 388
	  		  	1    VTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSELWAEAGKLGFLGVNLPE   60
			  	61   EYGGGGAGMYELSLVMEEMAAAGSALLLMVVSPAINGTIIAKFGTDDQKKRWLPGIADGS  120
			  	121  LTMAFAITEPDAGSNSHKITTTARRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTG  180
			  	181  KLRPALFVVPTDAPGFSYTPIEMELVSPERQFQVFLDDVRLPADALVGAEDAAIAQLFAG  240
			  	241  LNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQCHIEVELAKLM  300
			  	301  TQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAVQSMGGNGLTKEYGVAAMMTSA  360
			  	361  RLARIAPISREMVLNFVAQTSLGLPRSY

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 9 to 120  |  Coverage: 28% Acyl-CoA_dh_N Range: 124 to 176  |  Coverage: 13% Acyl-CoA_dh_M Range: 234 to 382  |  Coverage: 38% Acyl-CoA_dh_1 Range: 6 to 382  |  Coverage: 96% 1 Range: 1 to 388  |  Coverage: 99% 1 Range: 229 to 388  |  Coverage: 40% 2 Range: 1 to 234  |  Coverage: 60% 3 Range: 9 to 120  |  Coverage: 28% 4 Range: 121 to 243  |  Coverage: 31% 5
Number of amino acids : 388
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027719-120
Acyl-CoA_dh_MPF02770124-176
Acyl-CoA_dh_1PF00441234-382
Mtb Structural Proteome models
Model Number1
Model nameRv0972c
Template2D29    APDBCREDO
Template coverage5_384
Template Identity(%)28.9
Model coverage(%)96.9
Normalized DOPE score-0.443

Structure Models from Chopin
Model Number1
Profilea.29.3.1, e.6.1.1 - 1.10.540.10, 1.20.140.10, 2.40.110.10
Click for model details
zscore69.71
Residue begin1
Residue end388
Model Number2
Profilea.29.3.1
Click for model details
zscore31.04
Residue begin229
Residue end388
Model Number3
Profilee.6.1.1
Click for model details
zscore21.99
Residue begin1
Residue end234
Model Number4
Profile1.10.540.10
Click for model details
zscore21.44
Residue begin9
Residue end120
Model Number5
Profile2.40.110.10
Click for model details
zscore17.82
Residue begin121
Residue end243
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0972cGene nameConfidence Score
Rv0971cechA70.99
Rv0976cRv0976c0.964
Rv3516echA190.92
Rv2790cltp10.915
Rv2790cltp10.915
Rv0860fadB0.908
Rv0860fadB0.908
Rv1070cechA80.908
Rv0860fadB0.908
Rv0973caccA20.907
Rv1071cechA90.907
Rv0973caccA20.907
Rv0973caccA20.907
Rv0973caccA20.907
Rv1071cechA90.907
Rv0975cfadE130.906
Rv0975cfadE130.906
Rv0975cfadE130.906
Rv3561fadD30.901
Rv3561fadD30.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.922785.55
coenzyme APubChem0.902767.534
c1137PubChem0.9875.672
H(+)PubChem0.92.01588
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
C16468PubChem0.9875.672
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
5-methylhex-4-enoyl-CoAPubChem0.9877.688
AR-1A9122PubChem0.9787.566
Co-APubChem0.9767.534
1,5-dihydro-FADPubChem0.9787.566
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
adenosine monophosphatePubChem0.9347.221
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
NSC112207PubChem0.9785.55
formatePubChem0.945.0174