Rv3546

Tuberculist information
Gene namefadA5
Protein functionProbable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3985.56
Molecular mass(da)41328.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 391
	  		  	1    MGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQSGLHAGDVEQVIGGCV   60
			  	61   TQFGEQSNNISRVAWLTAGLPEHVGATTVDCQCGSGQQANHLIAGLIAAGAIDVGIACGI  120
			  	121  EAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAKRRGITREDVDVFGLESQRRA  180
			  	181  QRAWAEGRFDREISPIQAPVLDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGIH  240
			  	241  TAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQALVGAEPYYHLDGPVQSTAKVLE  300
			  	301  KAGMKIGDIDIVEINEAFASVVLSWARVHEPDMDRVNVNGGAIALGHPVGCTGSRLITTA  360
			  	361  LHELERTDQSLALITMCAGGALSTGTIIERI

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 1 to 261  |  Coverage: 66% Thiolase_N Range: 268 to 390  |  Coverage: 31% Thiolase_C Range: 3 to 389  |  Coverage: 98% 1 Range: 1 to 266  |  Coverage: 67% 1
Number of amino acids : 391
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_NPF001081-261
Thiolase_CPF02803268-390
Mtb Structural Proteome models
Model Number1
Model nameRv3546
Template1ULQ    APDBCREDO
Template coverage3_398
Template Identity(%)40.1
Model coverage(%)98.7
Normalized DOPE score-0.469

Structure Models from Chopin
Model Number1
Profilec.95.1.1
Click for model details
zscore39.2
Residue begin1
Residue end266
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3546Gene nameConfidence Score
Rv2504cscoA0.977
Rv0468fadB20.971
Rv0468fadB20.971
Rv0860fadB0.968
Rv0860fadB0.968
Rv0860fadB0.968
Rv2503cscoB0.963
Rv3667acs0.957
Rv3667acs0.957
Rv1715fadB30.948
Rv1715fadB30.948
Rv0896gltA20.942
Rv0975cfadE130.94
Rv0975cfadE130.94
Rv0975cfadE130.94
Rv3140fadE230.935
Rv3140fadE230.935
Rv0408pta0.934
Rv0408pta0.934
Rv0408pta0.934
Rv3535chsaG0.932
Rv3535chsaG0.932
Rv1131prpC0.929
Rv2790cltp10.925
Rv2790cltp10.925
Rv0154cfadE20.918
Rv0154cfadE20.918
Rv0154cfadE20.918
Rv0131cfadE10.912
Rv0131cfadE10.912
Rv0131cfadE10.912
Rv0889ccitA0.91
Rv0904caccD30.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.979851.607
acetyl-CoAPubChem0.937809.571
coenzyme APubChem0.925767.534
3-hydroxybutyryl-CoAPubChem0.913853.623
butyryl-CoAPubChem0.913837.624
Co-APubChem0.91767.534
NAD+PubChem0.903663.425
3-ketohexanoyl-CoAPubChem0.902879.661
deuteriumPubChem0.9012.01588
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
acetyl coenzyme-APubChem0.9809.571
carbon dioxidePubChem0.944.0095
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
pyruvic acidPubChem0.988.0621
acetoacetyl-S-CoAPubChem0.9851.607
H(+)PubChem0.92.01588
protiumPubChem0.92.01576
acetoacetyl-coenzyme APubChem0.762851.607