Rv2503c

Tuberculist information
Gene namescoB
Protein functionProbable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2818.47
Molecular mass(da)22898.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 218
	  		  	1    MSAPGWSRDEMAARVAAEFEDGQYVNLGIGMPTLIPNHIPDGVHVVLHSENGILGVGPYP   60
			  	61   RREDVDADLINAGKETVTTLPGAAFFSSSTSFGIIRGGHLDVAVLGAMQVSVTGDLANWM  120
			  	121  IPGKMVKGMGGAMDLVHGARKVIVMMEHTAKDGSPKILERCTLPLTGVGCVDRIVTELAV  180
			  	181  IDVCADGLHLVQTAPGVSVDEVVAKTQPPLVLRDLATQ

Known structures in the PDB
No Known structures
1 22 43 64 85 106 127 148 169 190 211 Range: 8 to 205  |  Coverage: 90% CoA_trans Range: 6 to 217  |  Coverage: 96% 1 Range: 3 to 218  |  Coverage: 98% 1
Number of amino acids : 218
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CoA_transPF011448-205
Mtb Structural Proteome models
Model Number1
Model nameRv2503c
Template1OOY    APDBCREDO
Template coverage261_475
Template Identity(%)57.5
Model coverage(%)96.8
Normalized DOPE score-0.464

Structure Models from Chopin
Model Number1
Profilec.124.1.3
Click for model details
zscore35.6
Residue begin3
Residue end218
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2503cGene nameConfidence Score
Rv2504cscoA0.999
Rv1323fadA40.985
Rv1323fadA40.985
Rv0859fadA0.979
Rv0859fadA0.979
Rv1074cfadA30.977
Rv1074cfadA30.977
Rv3556cfadA60.974
Rv3556cfadA60.974
Rv3546fadA50.963
Rv3546fadA50.963
Rv0468fadB20.946
Rv0468fadB20.946
Rv1715fadB30.942
Rv1715fadB30.942
Rv0243fadA20.93
Rv0243fadA20.93
Rv0914cRv0914c0.93
Rv0914cRv0914c0.93
Rv0860fadB0.914
Rv0860fadB0.914
Rv0860fadB0.914
Rv3523ltp30.91
Rv2498ccitE0.905
Rv2502caccD10.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
succinyl-CoAPubChem0.984867.607
succinyl-coenzyme APubChem0.961867.607
beta-ketoadipatePubChem0.956160.125
acetoacetatePubChem0.955102.089
acetyl-CoAPubChem0.926809.571
acetoacetyl-CoAPubChem0.925851.607
3-oxoadipate enol-lactonePubChem0.922142.109
succinatePubChem0.919118.088
coenzyme APubChem0.917767.534
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
beta-ketoadipyl-CoAPubChem0.9909.644
Co-APubChem0.9767.534
acetoacetyl-coenzyme APubChem0.9851.607
3-oxoadipyl-CoAPubChem0.9908.636
acetyl coenzyme-APubChem0.9809.571
hydroxyl radicalsPubChem0.917.0073
suc-coaPubChem0.9867.607