Tuberculist information
Gene namehsaG
Protein functionProbable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating])
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3973.59
Molecular mass(da)32008.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 303
	  		  	1    MPSKAKVAIVGSGNISTDLLYKLLRSEWLEPRWMVGIDPESDGLARAAKLGLETTHEGVD   60
			  	61   WLLAQPDKPDLVFEATSAYVHRDAAPKYAEAGIRAIDLTPAAVGPAVIPPANLREHLDAP  120
			  	121  NVNMITCGGQATIPIVYAVSRIVEVPYAEIVASVASVSAGPGTRANIDEFTKTTARGVQT  180
			  	181  IGGAARGKAIIILNPADPPMIMRDTIFCAIPTDADREAIAASIHDVVKEVQTYVPGYRLL  240
			  	241  NEPQFDEPSINSGGQALVTTFVEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAKETLVVG  300
			  	301  GAR
			  			

Known structures in the PDB
PDB ID4JN6
Total residue count1304
Number of chains4
MethodX-RAY
Resolution1.93
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Semialdhyde_dhPF011186-119
AcetDehyd-dimerPF09290127-272
Mtb Structural Proteome models
Model Number1
Model nameRv3535c
Template1NVM    BPDBCREDO
Template coverage1_312
Template Identity(%)57.5
Model coverage(%)98.3
Normalized DOPE score-0.992

Structure Models from Chopin
Model Number1
Profilec.25.1.3
Click for model details
zscore6.9
Residue begin6
Residue end119
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3535cGene nameConfidence Score
Rv3534chsaF0.999
Rv3534chsaF0.999
Rv3536chsaE0.998
Rv3469cmhpE0.998
Rv0408pta0.986
Rv0408pta0.986
Rv0408pta0.986
Rv0458Rv04580.977
Rv2858caldC0.975
Rv0768aldA0.971
Rv3667acs0.954
Rv3667acs0.954
Rv1074cfadA30.945
Rv1074cfadA30.945
Rv3569chsaD0.942
Rv3556cfadA60.939
Rv3556cfadA60.939
Rv0859fadA0.934
Rv0859fadA0.934
Rv3546fadA50.932
Rv3546fadA50.932
Rv0914cRv0914c0.93
Rv0914cRv0914c0.93
Rv1323fadA40.927
Rv1323fadA40.927
Rv0243fadA20.921
Rv0243fadA20.921
Rv2495cbkdC0.913
Rv2495cbkdC0.913
Rv0147Rv01470.913
Rv2495cbkdC0.913
Rv3086adhD0.905
Rv3086adhD0.905
Rv0409ackA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ethanolPubChem0.96746.0684
acetyl-CoAPubChem0.965809.571
acetaldehydePubChem0.96244.0526
coenzyme APubChem0.953767.534
formatePubChem0.92845.0174
Co-APubChem0.924767.534
L-allo-threoninePubChem0.92119.119
NAD+PubChem0.919663.425
L-threoninePubChem0.912119.119
acetyl coenzyme-APubChem0.9809.571
butyraldehydePubChem0.972.1057
pyruvic acidPubChem0.988.0621
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
deuteriumPubChem0.92.01588
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
H(+)PubChem0.92.01588
butyryl-CoAPubChem0.9837.624
protiumPubChem0.92.01576
polyglycinePubChem0.975.0666