Rv3534c

Tuberculist information
Gene namehsaF
Protein functionProbable 4-hydroxy-2-oxovalerate aldolase (HOA)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3972.55
Molecular mass(da)36442.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 346
	  		  	1    MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPVIEVTHGDGLGGSSFNY   60
			  	61   GFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVS  120
			  	121  IQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVAD  180
			  	181  RVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEAL  240
			  	241  IGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKHAVRQA  300
			  	301  ERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVTH

Known structures in the PDB
PDB ID4JN6
Total residue count1304
Number of chains4
MethodX-RAY
Resolution1.93
1 35 69 103 137 171 205 239 273 307 341 Range: 15 to 248  |  Coverage: 67% HMGL-like Range: 272 to 337  |  Coverage: 18% DmpG_comm Range: 9 to 334  |  Coverage: 93% 1 Range: 1 to 339  |  Coverage: 97% 1 Range: 15 to 248  |  Coverage: 67% 2 Range: 288 to 336  |  Coverage: 13% 3
Number of amino acids : 346
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HMGL-likePF0068215-248
DmpG_commPF07836272-337
Mtb Structural Proteome models
Model Number1
Model nameRv3534c
Template1NVM    APDBCREDO
Template coverage11_336
Template Identity(%)49.7
Model coverage(%)93.9
Normalized DOPE score-1.131

Structure Models from Chopin
Model Number1
Profilea.5.7.1, c.1.10.5 - 1.10.8.60, 3.20.20.70
Click for model details
zscore49.61
Residue begin1
Residue end339
Model Number2
Profilec.1.10.5
Click for model details
zscore32.39
Residue begin15
Residue end248
Model Number3
Profilea.5.7.1
Click for model details
zscore7.46
Residue begin288
Residue end336
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3534cGene nameConfidence Score
Rv3535chsaG0.999
Rv3535chsaG0.999
Rv3536chsaE0.999
Rv3469cmhpE0.918
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetaldehydePubChem0.94444.0526
4-hydroxy-2-oxovaleratePubChem0.936132.115
HKPPubChem0.935132.115
pyruvic acidPubChem0.92588.0621