Rv3469c

Tuberculist information
Gene namemhpE
Protein functionProbable 4-hydroxy-2-oxovalerate aldolase MhpE (HOA)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3886.07
Molecular mass(da)36297.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 336
	  		  	1    MLMTATHREPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAA   60
			  	61   AQGPAAHTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGDYLDFLRICVIATEFEL  120
			  	121  VMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDAR  180
			  	181  RYVEALRGASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLV  240
			  	241  AALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRAAAQ  300
			  	301  QAGLSVSHVIRQTAKSHAGQWLSPQDIDRVVVGMRA

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 18 to 247  |  Coverage: 68% HMGL-like Range: 6 to 317  |  Coverage: 92% 1 Range: 1 to 291  |  Coverage: 86% 1
Number of amino acids : 336
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HMGL-likePF0068218-247
Mtb Structural Proteome models
Model Number1
Model nameRv3469c
Template1NVM    APDBCREDO
Template coverage5_320
Template Identity(%)28.8
Model coverage(%)92.6
Normalized DOPE score-1.105

Structure Models from Chopin
Model Number1
Profilec.1.10.5
Click for model details
zscore28.49
Residue begin1
Residue end291
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3469cGene nameConfidence Score
Rv3535chsaG0.998
Rv3535chsaG0.998
Rv3536chsaE0.993
Rv3534chsaF0.918
Rv3534chsaF0.918
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetaldehydePubChem0.91244.0526
4-hydroxy-2-oxovaleratePubChem0.911132.115
HKPPubChem0.911132.115
pyruvic acidPubChem0.90388.0621