Rv3536c

Tuberculist information
Gene namehsaE
Protein functionProbable hydratase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3974.51
Molecular mass(da)27891.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 261
	  		  	1    MLRDATRDELAADLAQAERSRDPIGQLTAAHPEIDVVDAYEIQLINIRQRVAEGARVVGH   60
			  	61   KVGLSSPIMQQMMGVDEPDYGHLLDDMQVFEDTPVQASRYLSPRVEVEVGFILAADLPGA  120
			  	121  GCTEDDVLAATEALVPAIELIDTRIKDWQIKICDTIADNASAAGFVLGAARVPPADLDVR  180
			  	181  AIDAKLTRNGEVVAEGRSDAVLGNPATAVAWLAGKVESFGVRLRKGDIVLPGSCTFAVEA  240
			  	241  RAGDEFVADFTGLGLVRLSFE

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 56 to 261  |  Coverage: 78% FAA_hydrolase Range: 2 to 260  |  Coverage: 98% 1 Range: 1 to 261  |  Coverage: 99% 1
Number of amino acids : 261
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FAA_hydrolasePF0155756-261
Mtb Structural Proteome models
Model Number1
Model nameRv3536c
Template1SV6    APDBCREDO
Template coverage1_259
Template Identity(%)42.1
Model coverage(%)98.5
Normalized DOPE score-0.738

Structure Models from Chopin
Model Number1
Profiled.177.1.1 - 3.90.850.10
Click for model details
zscore28.32
Residue begin1
Residue end261
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3536cGene nameConfidence Score
Rv3534chsaF0.999
Rv3534chsaF0.999
Rv3535chsaG0.998
Rv3535chsaG0.998
Rv3469cmhpE0.993
Rv3569chsaD0.991
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
2-hydroxypenta-2,4-dienoatePubChem0.962114.099
4-hydroxy-2-oxovaleratePubChem0.947132.115
HKPPubChem0.946132.115
phosphatePubChem0.72296.9872
Na(+)PubChem0.70622.9898