Rv3086

Tuberculist information
Gene nameadhD
Protein functionProbable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3451.78
Molecular mass(da)38341.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 368
	  		  	1    MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPRFPIVGG   60
			  	61   HEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYCCTGRQNLCDMGATILEGCMPDGS  120
			  	121  FRFHSQGTDFGAMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAG  180
			  	181  NLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASA  240
			  	241  AAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTD  300
			  	301  LTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGK  360
			  	361  NIRGVIVH

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 27 to 153  |  Coverage: 34% ADH_N Range: 195 to 327  |  Coverage: 35% ADH_zinc_N Range: 1 to 368  |  Coverage: 99% 1 Range: 1 to 368  |  Coverage: 99% 1 Range: 27 to 153  |  Coverage: 34% 2 Range: 1 to 359  |  Coverage: 97% 3 Range: 163 to 341  |  Coverage: 48% 4
Number of amino acids : 368
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ADH_NPF0824027-153
ADH_zinc_NPF00107195-327
Mtb Structural Proteome models
Model Number1
Model nameRv3086
Template1P0F    APDBCREDO
Template coverage1007_1372
Template Identity(%)33.1
Model coverage(%)99.7
Normalized DOPE score-0.572

Structure Models from Chopin
Model Number1
Profile3.40.50.720, 3.90.180.10
Click for model details
zscore35.13
Residue begin1
Residue end368
Model Number2
Profile3.90.180.10
Click for model details
zscore23.18
Residue begin27
Residue end153
Model Number3
Profile3.90.180.10
Click for model details
zscore17.46
Residue begin1
Residue end359
Model Number4
Profilec.2.1.1 - 3.40.50.720
Click for model details
zscore10.79
Residue begin163
Residue end341
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3086Gene nameConfidence Score
Rv3085Rv30850.956
Rv3087Rv30870.95
Rv3087Rv30870.95
Rv3088tgs40.95
Rv3088tgs40.95
Rv2259mscR0.92
Rv2259mscR0.92
Rv0162cadhE10.918
Rv0162cadhE10.918
Rv3089fadD130.917
Rv3089fadD130.917
Rv0761cadhB0.908
Rv0761cadhB0.908
Rv0761cadhB0.908
Rv3084lipR0.907
Rv3535chsaG0.905
Rv3535chsaG0.905
Rv3083Rv30830.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.974663.425
methanolPubChem0.93830.026
reduced nicotinamide adenine dinucleotidePubChem0.928665.441
H(+)PubChem0.9162.01588
deuteriumPubChem0.9052.01588
dihydronicotinamide formycin dinucleotidePubChem0.903665.441
1-(4'-hydroxyphenyl)ethanolPubChem0.9138.164
butyraldehydePubChem0.972.1057
protiumPubChem0.92.01576
zincPubChem0.81865.409
ethanolPubChem0.75246.0684