Rv3088

Tuberculist information
Gene nametgs4
Protein functionPutative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4
Functional category(tuberculist)lipid metabolism
Gene location(kb)3454.34
Molecular mass(da)50886.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 474
	  		  	1    MTRINPIDLSFLLLERANRPNHMAAYTIFEKPKGQKSSFGPRLFDAYRHSQAAKPFNHKL   60
			  	61   KWLGTDVAAWETVEPDMGYHIRHLALPAPGSMQQFHETVSFLNTGLLDRGHPMWECYIID  120
			  	121  GIERGRIAILLKVHHALIDGEGGLRAMRNFLSDSPDDTTLAGPWMSAQGADRPRRTPATV  180
			  	181  SRRAQLQGQLQGMIKGLTKLPSGLFGVSADAADLGAQALSLKARKASLPFTARRTLFNNT  240
			  	241  AKSAARAYGNVELPLADVKALAKATGTSVNDVVMTVIDDALHHYLAEHQASTDRPLVAFM  300
			  	301  PMSLREKSGEGGGNRVSAELVPMGAPKASPVERLKEINAATTRAKDKGRGMQTTSRQAYA  360
			  	361  LLLLGSLTVADALPLLGKLPSANVVISNMKGPTEQLYLAGAPLVAFSGLPIVPPGAGLNV  420
			  	421  TFASINTALCIAIGAAPEAVHEPSRLAELMQRAFTELQTEAGTTSPTTSKSRTP

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 4 to 273  |  Coverage: 56% WES_acyltransf Range: 306 to 460  |  Coverage: 32% DUF1298 Range: 3 to 456  |  Coverage: 95% 1 Range: 250 to 468  |  Coverage: 45% 1
Number of amino acids : 474
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
WES_acyltransfPF030074-273
DUF1298PF06974306-460
Mtb Structural Proteome models
Model Number1
Model nameRv3088
Template2BGH    APDBCREDO
Template coverage27_417
Template Identity(%)10.6
Model coverage(%)95.6
Normalized DOPE score1.082

Structure Models from Chopin
Model Number1
Profilec.43.1.3
Click for model details
zscore4.14
Residue begin250
Residue end468
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3088Gene nameConfidence Score
Rv1543Rv15430.954
Rv3089fadD130.95
Rv3089fadD130.95
Rv3086adhD0.95
Rv3086adhD0.95
Rv3087Rv30870.933
Rv3087Rv30870.933
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions