Rv1543

Tuberculist information
Gene nameRv1543
Protein functionPossible fatty acyl-CoA reductase
Functional category(tuberculist)lipid metabolism
Gene location(kb)1745.06
Molecular mass(da)36820.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 341
	  		  	1    MNLGDLTNFVEKPLAAVSNIVNTPNSAGRYRPFYLRNLLDAVQGRNLNDAVKGKVVLITG   60
			  	61   GSSGIGAAAAKKIAEAGGTVVLVARTLENLENVANDIRAIRGNGGTAHVYPCDLSDMDAI  120
			  	121  AVMADQVLGDLGGVDILINNAGRSIRRSLELSYDRIHDYQRTMQLNYLGAVQLILKFIPG  180
			  	181  MRERHFGHIVNVSSVGVQTRAPRFGAYIASKAALDSLCDALQAETVHDNVRFTTVHMALV  240
			  	241  RTPMISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPFGQFAAVADAVNPAVMDRVR  300
			  	301  NRAFNMFGDSSAAKGSESQTDTSELDKRSETFVRATRGIHW

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 54 to 226  |  Coverage: 50% adh_short Range: 50 to 333  |  Coverage: 82% 1 Range: 1 to 341  |  Coverage: 99% 1
Number of amino acids : 341
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
adh_shortPF0010654-226
Mtb Structural Proteome models
Model Number1
Model nameRv1543
Template1XHL    APDBCREDO
Template coverage3_276
Template Identity(%)24.8
Model coverage(%)83.0
Normalized DOPE score-0.101

Structure Models from Chopin
Model Number1
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore14.53
Residue begin1
Residue end341
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1543Gene nameConfidence Score
Rv3734ctgs20.958
Rv1760Rv17600.957
Rv3088tgs40.954
Rv3088tgs40.954
Rv3087Rv30870.944
Rv3087Rv30870.944
Rv3371Rv33710.926
Rv3480cRv3480c0.919
Rv3480cRv3480c0.919
Rv1544Rv15440.912
Rv2285Rv22850.903
Rv2285Rv22850.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
H(+)PubChem0.92.01588
palmitoyl-CoAPubChem0.91005.94
Co-APubChem0.9767.534
coenzyme APubChem0.9767.534
NAD+PubChem0.9663.425
palmitoylPubChem0.9240.425