Rv3734c

Tuberculist information
Gene nametgs2
Protein functionPutative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs2
Functional category(tuberculist)lipid metabolism
Gene location(kb)4184.53
Molecular mass(da)49303.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 454
	  		  	1    MDLMMPNDSMFLFIESREHPMHVGGLSLFEPPQGAGPEFVREFTERLVANDEFQPMFRKH   60
			  	61   PATIGGGIARVAWAYDDDIDIDYHVRRSALPSPGRVRDLLELTSRLHTSLLDRHRPLWEL  120
			  	121  HVVEGLNDGRFAMYTKMHHALIDGVSAMKLAQRTLSADPDDAEVRAIWNLPPRPRTRPPS  180
			  	181  DGSSLLDALFKMAGSVVGLAPSTLKLARAALLEQQLTLPFAAPHSMFNVKVGGARRCAAQ  240
			  	241  SWSLDRIKSVKQAAGVTVNDAVLAMCAGALRYYLIERNALPDRPLIAMVPVSLRSKEDAD  300
			  	301  AGGNLVGSVLCNLATHVDDPAQRIQTISASMDGNKKVLSELPQLQVLALSALNMAPLTLA  360
			  	361  GVPGFLSAVPPPFNIVISNVPGPVDPLYYGTARLDGSYPLSNIPDGQALNITLVNNAGNL  420
			  	421  DFGLVGCRRSVPHLQRLLAHLESSLKDLEQAVGI

Known structures in the PDB
No Known structures
1 46 91 136 181 226 271 316 361 406 451 Range: 4 to 262  |  Coverage: 56% WES_acyltransf Range: 7 to 450  |  Coverage: 97% 1
Number of amino acids : 454
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
WES_acyltransfPF030074-262
Mtb Structural Proteome models
Model Number1
Model nameRv3734c
Template1L5A    APDBCREDO
Template coverage4_406
Template Identity(%)16.6
Model coverage(%)97.6
Normalized DOPE score0.806

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3734cGene nameConfidence Score
Rv1543Rv15430.958
Rv3391acrA10.94
Rv3391acrA10.94
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions