Rv2285

Tuberculist information
Gene nameRv2285
Protein functionPossible triacylglycerol synthase (diacylglycerol acyltransferase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2557.47
Molecular mass(da)47675
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 445
	  		  	1    VKLLSPLDQMFARMEAPRTPMHIGAFAVFDLPKGAPRRFIRDLYEAISQLAFLPFPFDSV   60
			  	61   IAGGASMAYWRQVQPDPSYHVRLSALPYPGTGRDLGALVERLHSTPLDMAKPLWELHLIE  120
			  	121  GLTGRQFAMYFKAHHCAVDGLGGVNLIKSWLTTDPEAPPGSGKPEPFGDDYDLASVLAAA  180
			  	181  TTKRAVEGVSAVSELAGRLSSMVLGANSSVRAALTTPRTPFNTRVNRHRRLAVQVLKLPR  240
			  	241  LKAVAHATDCTVNDVILASVGGACRRYLQELGDLPTNTLTASVPVGFERDADTVNAASGF  300
			  	301  VAPLGTSIEDPVARLTTISASTTRGKAELLAMSPNALQHYSVFGLLPIAVGQKTGALGVI  360
			  	361  PPLFNFTVSNVVLSKDPLYLSGAKLDVIVPMSFLCDGYGLNVTLVGYTDKVVLGFLGCRD  420
			  	421  TLPHLQRLAQYTGAAFEELETAALP

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 4 to 256  |  Coverage: 56% WES_acyltransf Range: 295 to 442  |  Coverage: 33% DUF1298 Range: 4 to 442  |  Coverage: 98% 1
Number of amino acids : 445
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
WES_acyltransfPF030074-256
DUF1298PF06974295-442
Mtb Structural Proteome models
Model Number1
Model nameRv2285
Template1L5A    APDBCREDO
Template coverage1_407
Template Identity(%)11.5
Model coverage(%)98.4
Normalized DOPE score0.312

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2285Gene nameConfidence Score
Rv1543Rv15430.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions