Rv3087

Tuberculist information
Gene nameRv3087
Protein functionPossible triacylglycerol synthase (diacylglycerol acyltransferase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3452.93
Molecular mass(da)52597.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 472
	  		  	1    MRRLNGVDALMLYLDGGSAYNHTLKISVLDPSTDPDGWSWPKARQMFEERAHLLPVFRLR   60
			  	61   YLPTPLGLHHPIWVEDPEFDLDAHVRRVVCPAPGGMAEFCALVEQIYAHPLDRDRPLWQT  120
			  	121  WVVEGLDGGRVALVTLLHHAYSDGVGVLDMLAAFYNDTPDEAPVVAPPWEPPPLPSTRQR  180
			  	181  LGWALRDLPSRLGKIAPTVRAVRDRVRIEREFAKDGDRRVPPTFDRSAPPGPFQRGLSRS  240
			  	241  RRFSCESFPLAEVREVSKTLGVTINDVFLACVAGAVRRYLERCGSPPTDAMVATMPLAVT  300
			  	301  PAAERAHPGNYSSVDYVWLRADIADPLERLHATHLAAEATKQHFAQTKDADVGAVVELLP  360
			  	361  ERLISGLARANARTKGRFDTFKNVVVSNVPGPREPRYLGRWRVDQWFSTGQISHGATLNM  420
			  	421  TVWSYCDQFNLCVMADAVAVRNTWELLGGFRASHEELLAAARAQATPKEMAT

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 4 to 268  |  Coverage: 55% WES_acyltransf Range: 304 to 460  |  Coverage: 33% DUF1298 Range: 4 to 472  |  Coverage: 99% 1 Range: 1 to 193  |  Coverage: 40% 1 Range: 242 to 468  |  Coverage: 47% 2
Number of amino acids : 472
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
WES_acyltransfPF030074-268
DUF1298PF06974304-460
Mtb Structural Proteome models
Model Number1
Model nameRv3087
Template1L5A    APDBCREDO
Template coverage1_419
Template Identity(%)13.1
Model coverage(%)99.2
Normalized DOPE score0.481

Structure Models from Chopin
Model Number1
Profilec.43.1.2
Click for model details
zscore4.74
Residue begin1
Residue end193
Model Number2
Profilec.43.1.3
Click for model details
zscore4.64
Residue begin242
Residue end468
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3087Gene nameConfidence Score
Rv3089fadD130.952
Rv3089fadD130.952
Rv3086adhD0.95
Rv3086adhD0.95
Rv1543Rv15430.944
Rv3088tgs40.933
Rv3088tgs40.933
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions