Rv3083

Tuberculist information
Gene nameRv3083
Protein functionProbable monooxygenase (hydroxylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3448.5
Molecular mass(da)55482.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 495
	  		  	1    MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMF   60
			  	61   TFGYKFRPWRDVKVLADGASIRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAG  120
			  	121  VHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKV  180
			  	181  VVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY  240
			  	241  EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAV  300
			  	301  PNGDLFKTLASGAASVVTDQIETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIV  360
			  	361  DGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTV  420
			  	421  ATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD  480
			  	481  GVLHFAAAAQDHAAA

Known structures in the PDB
No Known structures
1 50 99 148 197 246 295 344 393 442 491 Range: 8 to 217  |  Coverage: 42% Pyr_redox_3 Range: 2 to 486  |  Coverage: 97% 1 Range: 3 to 237  |  Coverage: 47% 1
Number of amino acids : 495
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pyr_redox_3PF137388-217
Mtb Structural Proteome models
Model Number1
Model nameRv3083
Template1W4X    APDBCREDO
Template coverage14_542
Template Identity(%)22.9
Model coverage(%)97.8
Normalized DOPE score0.194

Structure Models from Chopin
Model Number1
Profilec.3.1.7
Click for model details
zscore6.5
Residue begin3
Residue end237
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3083Gene nameConfidence Score
Rv3085Rv30850.955
Rv3082cvirS0.939
Rv3082cvirS0.939
Rv3084lipR0.938
Rv3089fadD130.936
Rv3089fadD130.936
Rv3086adhD0.902
Rv3086adhD0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions