Rv3082c

Tuberculist information
Gene namevirS
Protein functionVirulence-regulating transcriptional regulator VirS (AraC/XylS family)
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)3447.4
Molecular mass(da)37789.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 340
	  		  	1    MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQEDAFMSLAGFVRMLEASA   60
			  	61   AELDCPDFGLRLARWQGLGILGPVAVIARNAATLFGGLEAIGRYLYVHSPALTLTVSSTT  120
			  	121  ARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGPQARARVFSFRHAQLGTDAAY  180
			  	181  REALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRIATKYLESQYLPSDATLSERVVG  240
			  	241  LARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGLRCHDLIERERRAQAARYLAQPGLY  300
			  	301  LSQIAVLLGYSEQSALNRSCRRWFGMTPRQYRAYGGVSGR

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 23 to 208  |  Coverage: 54% Arabinose_bd Range: 256 to 334  |  Coverage: 22% HTH_18 Range: 231 to 332  |  Coverage: 29% 1 Range: 282 to 340  |  Coverage: 17% 1 Range: 186 to 280  |  Coverage: 27% 2
Number of amino acids : 340
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Arabinose_bdPF1262523-208
HTH_18PF12833256-334
Mtb Structural Proteome models
Model Number1
Model nameRv3082c
Template1BL0    APDBCREDO
Template coverage9_110
Template Identity(%)20.6
Model coverage(%)29.7
Normalized DOPE score-0.746

Structure Models from Chopin
Model Number1
Profilea.4.1.8
Click for model details
zscore8.29
Residue begin282
Residue end340
Model Number2
Profilea.4.1.12 - 1.10.10.60
Click for model details
zscore4.02
Residue begin186
Residue end280
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3082cGene nameConfidence Score
Rv3083Rv30830.939
Rv3089fadD130.905
Rv3089fadD130.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions