Rv2259

Tuberculist information
Gene namemscR
Protein functionS-nitrosomycothiol reductase MscR
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2532.25
Molecular mass(da)37888.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 361
	  		  	1    MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYREGGINDEYPFL   60
			  	61   LGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACKRGRPRYCFDTFNAEQKMTLT  120
			  	121  DGTELTAALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRD  180
			  	181  DTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVDVVQAI  240
			  	241  GGLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGVPTPDMRLDMPLVDFFSHGGA  300
			  	301  LKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLEDVEEAFHKMHGGKVLRSVVM  360
			  	361  L

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 29 to 148  |  Coverage: 32% ADH_N Range: 190 to 324  |  Coverage: 37% ADH_zinc_N Range: 1 to 361  |  Coverage: 99% 1 Range: 1 to 361  |  Coverage: 99% 1 Range: 29 to 148  |  Coverage: 32% 2 Range: 1 to 291  |  Coverage: 80% 3 Range: 158 to 334  |  Coverage: 48% 4
Number of amino acids : 361
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ADH_NPF0824029-148
ADH_zinc_NPF00107190-324
Mtb Structural Proteome models
Model Number1
Model nameRv2259
Template1CDO    APDBCREDO
Template coverage3_374
Template Identity(%)34.1
Model coverage(%)99.7
Normalized DOPE score-0.417

Structure Models from Chopin
Model Number1
Profile3.40.50.720, 3.90.180.10
Click for model details
zscore30.89
Residue begin1
Residue end361
Model Number2
Profile3.90.180.10
Click for model details
zscore19.73
Residue begin29
Residue end148
Model Number3
Profile3.90.180.10
Click for model details
zscore13.96
Residue begin1
Residue end291
Model Number4
Profilec.2.1.1 - 3.40.50.720
Click for model details
zscore10.26
Residue begin158
Residue end334
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2259Gene nameConfidence Score
Rv2260Rv22600.942
Rv0761cadhB0.931
Rv0761cadhB0.931
Rv0761cadhB0.931
Rv3086adhD0.92
Rv3086adhD0.92
Rv0162cadhE10.916
Rv0162cadhE10.916
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.984663.425
reduced nicotinamide adenine dinucleotidePubChem0.924665.441
H(+)PubChem0.9142.01588
L-threoninePubChem0.912119.119
2-amino-3-ketobutyratePubChem0.912117.103
aminoacetonePubChem0.91173.0938
coenzyme APubChem0.905767.534
acetyl-CoAPubChem0.905809.571
deuteriumPubChem0.9042.01588
dihydronicotinamide formycin dinucleotidePubChem0.902665.441
carbon dioxidePubChem0.90244.0095
L-allo-threoninePubChem0.9119.119
protiumPubChem0.92.01576
Co-APubChem0.9767.534
AKBPubChem0.9117.103
polyglycinePubChem0.975.0666
acetyl coenzyme-APubChem0.9809.571
zincPubChem0.82665.409
ethanolPubChem0.746.0684