Rv1472

Tuberculist information
Gene nameechA12
Protein functionPossible enoyl-CoA hydratase EchA12 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1659.76
Molecular mass(da)30543.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 285
	  		  	1    VPHRCAAQVVAGYRSTVSLVLVEHPRPEIAQITLNRPERMNSMAFDVMVPLKEALAQVSY   60
			  	61   DNSVRVVVLTGAGRGFSPGADHKSAGVVPHVENLTRPTYALRSMELLDDVILMLRRLHQP  120
			  	121  VIAAVNGPAIGGGLCLALAADIRVASSSAYFRAAGINNGLTASELGLSYLLPRAIGSSRA  180
			  	181  FEIMLTGRDVSAEEAERIGLVSRQVPDEQLLDACYAIAARMAGFSRPGIELTKRTLWSGL  240
			  	241  DAASLEAHMQAEGLGQLFVRLLTANFEEAVAARAEQRAPVFTDDT

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 25 to 274  |  Coverage: 87% ECH Range: 20 to 236  |  Coverage: 75% 1 Range: 1 to 285  |  Coverage: 99% 1 Range: 223 to 285  |  Coverage: 21% 2
Number of amino acids : 285
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF0037825-274
Mtb Structural Proteome models
Model Number1
Model nameRv1472
Template2A7K    APDBCREDO
Template coverage1_210
Template Identity(%)32.5
Model coverage(%)75.8
Normalized DOPE score-0.737

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore36.49
Residue begin1
Residue end285
Model Number2
Profile1.10.12.10
Click for model details
zscore10.98
Residue begin223
Residue end285
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1472Gene nameConfidence Score
Rv1715fadB30.986
Rv1715fadB30.986
Rv1550fadD110.97
Rv0468fadB20.97
Rv0468fadB20.97
Rv0860fadB0.956
Rv0860fadB0.956
Rv0860fadB0.956
Rv1467cfadE150.925
Rv1467cfadE150.925
Rv1467cfadE150.925
Rv1467cfadE150.925
Rv1467cfadE150.925
Rv2502caccD10.91
Rv3761cfadE360.907
Rv0400cfadE70.905
Rv0400cfadE70.905
Rv0400cfadE70.905
Rv0244cfadE50.904
Rv0244cfadE50.904
Rv0244cfadE50.904
Rv0244cfadE50.904
Rv0244cfadE50.904
Rv3274cfadE250.903
Rv3274cfadE250.903
Rv3274cfadE250.903
Rv2724cfadE200.902
Rv2724cfadE200.902
Rv2724cfadE200.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.907835.608
3-hydroxybutyryl-CoAPubChem0.902853.623
C05268PubChem0.9881.677
C04405PubChem0.9867.65
C0885PubChem0.9917.752
methylcrotonyl CoAPubChem0.9849.635
C16468PubChem0.9875.672
AR-1A9122PubChem0.9787.566
c0887PubChem0.9935.767
flavin adenine dinucleotidePubChem0.9785.55
3-hydroxypropionyl-CoAPubChem0.9839.597
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05271PubChem0.9863.661
deuteriumPubChem0.92.01588
C11945PubChem0.9917.752
C05262PubChem0.9965.836
2-methylbutyryl-CoAPubChem0.9851.651
C01144PubChem0.9853.623
C05273PubChem0.9975.874
NAD+PubChem0.9663.425
protiumPubChem0.92.01576
2-methylacetoacetyl-coenzyme APubChem0.9865.634
C05266PubChem0.9909.73
3-methylcrotonyl-CoAPubChem0.9849.635
methacrylyl-CoAPubChem0.9835.608
C03221PubChem0.9947.821
hydroxyl radicalsPubChem0.917.0073
CHEBI:15477PubChem0.9851.651
NSC112207PubChem0.9785.55
3-hydroxypropionyl-coenzyme APubChem0.9839.597
C05258PubChem0.91021.94
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C16469PubChem0.9893.687
H(+)PubChem0.92.01588
C05275PubChem0.9919.768
1,5-dihydro-FADPubChem0.9787.566
C11947PubChem0.9935.767
C05260PubChem0.9993.889
2-methylacetoacetyl-CoAPubChem0.9865.634
acryloyl-CoAPubChem0.9821.581
trans-2-hexadecenoyl-CoAPubChem0.91003.93
2MCPubChem0.9835.608
C14145PubChem0.9911.659
3-hydroxydecanoyl-CoAPubChem0.9937.783
3-hydroxyadipyl-CoAPubChem0.9911.659
FADH2PubChem0.9787.566
C05276PubChem0.9891.714
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C11946PubChem0.9917.752
alpha-methylbutyryl-CoAPubChem0.9851.651